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| Nomenclature |
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Symbol:
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Lmf1cld
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Name:
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lipase maturation factor 1;
combined lipase deficiency
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MGI ID: |
MGI:1856820 |
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Synonyms: |
cld |
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Gene:
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Lmf1
Location:
Chr17:25579177-25662826 bp, + strand
Genetic Position: Chr17,
12.7 cM, cytoband A3.3
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Mutation
origin |
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Strain of Origin:
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M. m. musculus (Northern Jutland, Denmark)
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Viral insertion |
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Mutation details: This mutation was found as a "parasitic lethal" in tw73 and recovered from the haplotype by recombination. A full-length murine endogenous retrovirus (MuERV) is inserted into intron 7. This results in the expression of an aberrant mRNA that contains sequences derived from exons 1-7, but is missing sequences derived from exons 8-11. 400 bp of viral sequence replaced the missing sequences in the mRNA. (J:115044, J:130178)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Lmf1 tw73lab is one of three spontaneous, recessive, lethal mutations found in a wild-derived t haplotype. The other mutations are tw73 and tw73lab.
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| References |
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Original: |
J:7083
Paterniti JR Jr et al.,
"Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse."
Science 1983 Jul 8;221(4606):167-9
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All: |
11 reference(s)
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Analysis Tools
