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| Nomenclature |
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Symbol:
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Flt4Chy
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Name:
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FMS-like tyrosine kinase 4;
chylous ascites
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MGI ID: |
MGI:1856694 |
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Synonyms: |
Chy, Vegfr3TKmut |
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Gene:
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Flt4
Location:
Chr11:49609263-49652739 bp, + strand
Genetic Position: Chr11,
29.69 cM, cytoband A5-B1
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Defective lymphatic vessels in the Flt4Chy/Flt4+ mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: The mutation resulting in the Chy phenotype is an A-to-T mutation at position 3157 resulting in an isoleucine to phenylalanine substitution at position 1053 in the tyrosine kinase domain. This mutation is located in a highly conserved catalytic domain of the receptor, in close proximity to the VEGFR-3 mutations in human primary lymphedema. In addition, the Chy mutation was shown to be allelic to an existing targeted mutation in this gene. (J:72387)
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Inheritance: | |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:13981
Lyon MF et al.,
"Chylous ascites (Chy)"
Mouse News Lett 1984;71():26
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All: |
8 reference(s)
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Analysis Tools
