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| Nomenclature |
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Symbol:
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Col1a1Mov13
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Name:
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collagen, type I, alpha 1;
Moloney leukemia virus 13
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MGI ID: |
MGI:1856671 |
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Gene:
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Col1a1
Location:
Chr11:94936224-94953042 bp, + strand
Genetic Position: Chr11,
59.01 cM, cytoband D
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutation: | |
Viral insertion |
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Mutation details: Experimental integration of a proviral genome occurred in the first intron 19 base pairs downstream of the intron/exon boundary, and leads to complete transcriptional block in most cell types, except for odontoblasts and some osteoblasts. (J:7142, J:7398)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
A yeast artificial chromosome (YAC) 150 kb long that spans the Col1a1 gene has been introduced into fibroblasts carrying the Col1a1Mov13 mutation. The YAC complements the mutant gene, conferring normal collagen RNA expression (J:722). It can also be introduced transgenically into the germ line (J:4495).
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| References |
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Original: |
J:6514
Jaenisch R et al.,
"Chromosomal position and activation of retroviral genomes inserted into the germ line of mice."
Cell 1981 May;24(2):519-29
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All: |
13 reference(s)
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Analysis Tools
