Tyrc-14CoS
Radiation induced Allele Detail
|
|
| Nomenclature |
|
Symbol:
|
Tyrc-14CoS
|
|
Name:
|
tyrosinase;
albino deletion 14CoS, Oak Ridge
|
|
MGI ID: |
MGI:1856580 |
|
Synonyms: |
c14CoS, cA1, Fah- |
|
Gene:
|
Tyr
Location:
Chr7:87427405-87493411 bp, - strand
Genetic Position: Chr7,
49.01 cM
|
|
Mutation
origin |
|
Strain of Origin:
|
(101 x C3H)F1
|
|
Mutation
description |
|
Allele
Type: | |
Radiation induced |
|
Mutation: | |
Intergenic deletion |
| |
|
Large intergenic deletion. (J:5435)
|
|
Inheritance: | |
Recessive |
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
Tyrc-14CoS. This induced mutation was found at Oak Ridge National Laboratory. Homozygotes die neonatally (J:5063), and have deficiencies in activity of at least five liver enzymes, glucose-6-phosphatase, tyrosine aminotransferase, serine dehydratase, glutamine synthetase, and UDP-glucuronyltransferase, as well as low levels of liver microsomal cytochrome P-450 and the plasma proteins, albumin, a-fetoprotein, and transferrin (J:5715, J:5588, J:5730). Control of the level of two enzymes occurs at the transcriptional level; control of the level of the three plasma proteins occurs posttranscriptionally (J:7838, J:7840). There is a marked decrease in the number of receptors for insulin and glucocorticoids (J:6996) and for epidermal growth factor and glucagon (J:12047). Two specific liver polypeptides recognizable in two-dimensional gels are lacking (J:7420). The rough endoplasmic reticulum of the liver, and to a lesser extent of the kidneys, is dilated and vesiculated (J:5386). Complementation studies with other alleles have shown that this is probably the shortest of the six deletions (J:5435). It is known not to include the Mod2 locus (J:5437).
Compound heterozygotes carrying Tyrc-ch show dilution of the chinchilla pigmentation compared to homozygous chinchilla mice (Tyrc-ch/Tyrc-ch, J:5435).
|
| References |
|
Original: |
J:5063
Erickson RP et al.,
"Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse."
Proc Natl Acad Sci U S A 1968 Feb;59(2):437-44
|
|
All: |
27 reference(s)
|
|
|
Analysis Tools
