|
|
| Nomenclature |
|
Symbol:
|
Lepob
|
|
Name:
|
leptin;
obese
|
|
MGI ID: |
MGI:1856424 |
|
Synonyms: |
ob, ob/ob |
|
Gene:
|
Lep
Location:
Chr6:29060220-29073877 bp, + strand
Genetic Position: Chr6,
12.3 cM
|
|
Lepob/Lepob
Show the 2 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Strain of Origin:
|
STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs
|
|
Mutation
description |
|
Allele
Type: | |
Spontaneous |
|
Mutation: | |
Single point mutation |
| |
|
Mutation details: Sequencing of RT-PCR products revealed a nonsense mutation in codon 105 resulting from a C to T point mutation. The 16 kDa leptin protein, expressed predominantly in adipose tissue of normal mice, is missing from homozygous mutant mice (J:29081). (J:20512, J:29081, J:45748)
|
|
Inheritance: | |
Recessive |
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:13066
INGALLS AM et al.,
"Obese, a new mutation in the house mouse."
J Hered 1950 Dec;41(12):317-8
|
|
All: |
742 reference(s)
|
|
Analysis Tools
