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| Nomenclature |
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Symbol:
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Lepob
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Name:
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leptin;
obese
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MGI ID: |
MGI:1856424 |
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Synonyms: |
ob, ob/ob |
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Gene:
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Lep
Location:
Chr6:29060220-29073877 bp, + strand
Genetic Position: Chr6,
12.3 cM
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Lepob/Lepob
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Single point mutation |
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Mutation details: Sequencing of RT-PCR products revealed a nonsense mutation in codon 105 resulting from a C to T point mutation. The 16 kDa leptin protein, expressed predominantly in adipose tissue of normal mice, is missing from homozygous mutant mice (J:29081). (J:20512, J:29081, J:45748)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:13066
INGALLS AM et al.,
"Obese, a new mutation in the house mouse."
J Hered 1950 Dec;41(12):317-8
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All: |
746 reference(s)
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Analysis Tools
