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| Nomenclature |
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Symbol:
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a18H
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Name:
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nonagouti;
18 Harwell
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MGI ID: |
MGI:1856404 |
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Synonyms: |
Itch-, itchy |
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Gene:
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a
Location:
Chr2:154791402-155051012 bp, + strand
Genetic Position: Chr2,
76.83 cM
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Mutation
origin |
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Strain of Origin:
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C3H/HeH
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Mutation
description |
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Allele
Type: | |
Chemically and radiation induced |
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Mutation: | |
Inversion |
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Mutation details: This mutation comprises a paracentric inversion with deletions of 20 and 18 bp from the proximal and distal breakpoints, respectively. A probe from the agouti locus that differentiates polymorphisms between C3H/HeH and 101/H was used to show that the mutation arose on C3H/HeH. The mutating event affected the regulation of agouti, down regulating the expression of pheomelanin. The distal breakpoint is in the intron between exons 1 and 2 of the Itch gene and is responsible for an immunological defect.
(J:24934, J:45910)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:163587
Cattanach BM et al.,
"Agouti locus mutations at Harwell"
Mouse News Lett 1987;77():123-125
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All: |
17 reference(s)
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Analysis Tools
