Faslpr
Spontaneous Allele Detail
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| Nomenclature |
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Symbol:
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Faslpr
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Name:
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Fas (TNF receptor superfamily member 6);
lymphoproliferation
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MGI ID: |
MGI:1856334 |
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Synonyms: |
Fas-, Fas-def, lpr, MRL/lpr, Tnfrf6lpr, Tnfrsf6lpr, Tnfrsf6lpr |
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Gene:
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Fas
Location:
Chr19:34290659-34327770 bp, + strand
Genetic Position: Chr19,
29.48 cM
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control and Faslpr/Faslpr
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Other |
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Mutation details: Southern blotting experiments indicated that the mutation is a genomic rearrangement within the gene, probably within intron 2. (J:1181, J:4166, J:4342, J:14206, J:14503, J:15429)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Faslpr, lymphoproliferation, recessive. This mutation was found during inbreeding of a strain MRL/Mp derived from crosses among strains LG, AKR, C3H, and C57BL/6.
The resemblance has led to extensive use of Faslpr mice in attempts to determine the etiology of SLE and to evaluate therapies. However, the human APT1 gene (OMIM 134637) encodes the FAS antigen; Tnfrsf6 is not the homolog of the human (SLE) gene.
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| References |
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Original: |
J:28885
Murphy ED et al.,
"Autoimmunity and lymphoproliferation: Induction by mutant gene lpr, and acceleration by a male-associated factor in strain BXSB mice"
1978;():207-20
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All: |
725 reference(s)
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Analysis Tools
