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| Nomenclature |
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Symbol:
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Tyrc-112K
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Name:
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tyrosinase;
albino 112, Oak ridge
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MGI ID: |
MGI:1856308 |
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Synonyms: |
112K, c112K, cE, cE1' |
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Gene:
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Tyr
Location:
Chr7:87427405-87493411 bp, - strand
Genetic Position: Chr7,
49.01 cM
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Mutation
origin |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Radiation induced |
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Mutation: | |
Intergenic deletion |
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Mutation details: Large intergenic deletion. Tyrc-65K and Tyrc-112K are derived from the same male in matings sampling irradiated spermatogonial stem cells. They are presumed to have resulted from a single mutational event. (J:5386, J:23420)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
The phenotype of mice carrying this allele is similar to Tyrc-3H in most respects studied, including neonatal death, effect on liver enzymes and serum proteins (J:5435), and defective rough endoplasmic reticulum of liver (J:5386). Compound heterozygotes carrying Tyrc-ch show dilution of the chinchilla pigmentation compared to homozygous chinchilla mice (Tyrc-ch/Tyrc-ch, J:5435). Compound heterozygotes with Tyrc-6H show reproductive activity however embryos died at about 8 days gestation (J;5435).
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| References |
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Original: |
J:5435
Gluecksohn-Waelsch S et al.,
"Complementation studies of lethal alleles in the mouse causing deficiencies of glucose-6-phosphatase, tyrosine aminotransferase, and serine dehydratase."
Proc Natl Acad Sci U S A 1974 Mar;71(3):825-9
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All: |
20 reference(s)
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Analysis Tools
