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| Nomenclature |
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Symbol:
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Del(7)Tyrc-3H
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Name:
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deletion, Chr 7, albino 3 Harwell
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MGI ID: |
MGI:1856304 |
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Synonyms: |
c3, c3H, D7Ssb3Hp, Tyrc-3H |
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Gene:
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Del(7)Tyrc-3H
Location:
unknown
Genetic Position: Chr7,
Syntenic
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Mutation
origin |
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Strain of Origin:
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(C3H/HeH x 101/H)F1
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Mutation
description |
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Allele
Type: | |
Radiation induced |
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Mutation: | |
Intergenic deletion |
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Large intergenic deletion. (J:6053)
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Inheritance: | |
Not Specified |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Del(7)Tyrc-3H Mutation:
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0 strains or lines available |
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Notes |
This allele resembles two other induced mutant alleles, Tyrc-65K and Tyrc-112K, in most respects studied, including neonatal death, effect on liver enzymes and serum proteins (J:5435), and defective rough endoplasmic reticulum of liver (J:5386). Liver cells of homozygotes have reduced numbers of receptors for epidermal growth factor and glucagon (J:12047), and three specific liver polypeptides recognizable in two-dimensional gels are lacking (J:7420). Kidneys are severely reduced in size, but there are very few thymus abnormalities (J:5063). The deletion includes the Mod2 locus (J:6053). Heterozygous Tyrc-3H/Tyrc-6H mice are viable, but runted and sterile (J:6034). They have been used to study the effects of absence of mitochondrial malic enzyme caused by the absence of the Mod2 locus (J:6351).
Compound heterozygotes carrying Tyrc-ch show dilution of the chinchilla pigmentation compared to homozygous chinchilla mice (Tyrc-ch/Tyrc-ch, J:5435).
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| References |
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Original: |
J:5063
Erickson RP et al.,
"Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse."
Proc Natl Acad Sci U S A 1968 Feb;59(2):437-44
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All: |
16 reference(s)
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Analysis Tools
