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| Nomenclature |
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Symbol:
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KitW-sh
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Name:
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kit oncogene;
sash
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MGI ID: |
MGI:1856265 |
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Synonyms: |
Sash, Wsh, Wsh, W-sh |
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Gene:
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Kit
Location:
Chr5:75574916-75656722 bp, + strand
Genetic Position: Chr5,
39.55 cM
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Mutation
origin |
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Strain of Origin:
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(C3H/HeH x 101/H)F1
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Inversion |
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Mutation details: The molecular mutation of this allele is an inversion located proximal to the Kit structural gene that disrupts 5' regulatory sequences. Transcripts were not detectable from this allele in cultured mast cells derived from homozygous mice. However, an analysis of embryonic expression revealed that ectopic expression of Kit occurred in homozygous mice and normal expression was ablated. (J:2535, J:6857, J:13166, J:25082, J:29686)
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Inheritance: | |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:6857
Lyon MF et al.,
"A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice."
Genet Res 1982 Jun;39(3):315-22
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All: |
153 reference(s)
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Analysis Tools
