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| Nomenclature |
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Symbol:
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Cdh23v
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Name:
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cadherin 23 (otocadherin);
waltzer
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MGI ID: |
MGI:1856228 |
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Synonyms: |
v |
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Gene:
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Cdh23
Location:
Chr10:60302748-60696490 bp, - strand
Genetic Position: Chr10,
30.11 cM
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Mutation
origin |
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Strain of Origin:
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old mutant of the mouse fancy
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Insertion |
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Mutation details: A single G nucleotide insertion at position 889 is predicted to cause a frameshift and premature termination of the encoded protein. (J:69985, J:73941)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Viability and breeding ability are somewhat less than normal. Homozygotes show the typical circling, head-tossing, deafness, and hyperactivity of the circling mutants. Most of them are deaf from the beginning. Abnormalities of the inner ear include degeneration of the organ of Corti, spiral ganglion, stria vascularis, and saccular macula. Double heterozygotes with shaker-1 (Cdh23v/+ Myo7ash1/+) are deaf beginning at 3 to 6 months. They have changes similar to those of the homozygotes in the organ of Corti, stria vascularis, and spiral ganglion, but less severe and with much later onset (J:13130)(J:15164).
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| References |
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Analysis Tools
