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| Nomenclature |
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Symbol:
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Atp7aMo-to
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Name:
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ATPase, Cu++ transporting, alpha polypeptide;
tortoiseshell
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MGI ID: |
MGI:1856101 |
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Gene:
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Atp7a
Location:
ChrX:106027276-106124926 bp, + strand
Genetic Position: ChrX,
47.36 cM
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Atp7aMo-to/Atp7a+
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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obese stock
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Undefined |
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A spontaneous mutation that arose at The Jackson Laboratory in 1952.
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Inheritance: | |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Atp7aMo-to, tortoiseshell, semidominant. Arising spontaneously in an obese stock, the tortoiseshell mutation was considered to be a mottled locus allele because of its interaction with other alleles at the locus and because it shows about the same linkage relation with Zic3 (bent tail) as Atp7aMo (J:13382). Heterozygous females resemble Atp7a/+ females in color. The vibrissae are slightly wavy and the coat has a slightly silky texture. The distribution of patches of wild-type and white color is different from the distribution of patches of wild-type and wavy hair, suggesting that Atp7aMo-to probably acts independently in melanoblasts and hair follicles (J:15324). Most hemizygous males die before birth (J:24988), but a few are stillborn (J:12963). Using as parent a male presumed to be chimeric for Atp7aMo-to/Y and +/Y, Grahn et al. (J:12963) showed that homozygous Atp7aMo-to/Atp7aMo-to and heterozygous Atp7aMo-to/Atp7aMo-dp females die in utero, while heterozygous Atp7aMo-to/Atp7aMo-blo and Atp7aMo-to/Atp7aMo-br females reach term, but die by 15 days of age. The elastic lamina of the aorta is defective in stillborn hemizygous Atp7aMo-to males and in 40 per cent of Atp7aMo-to/+ female heterozygotes.
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| References |
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Original: |
J:24988
Dickie MM,
"The tortoise shell house mouse"
J Hered 1954;45():158 & 190
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All: |
10 reference(s)
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Analysis Tools
