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| Nomenclature |
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Symbol:
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MitfMi-wh
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Name:
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microphthalmia-associated transcription factor;
white
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MGI ID: |
MGI:1856088 |
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Synonyms: |
mitfwh, Miwh |
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Gene:
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Mitf
Location:
Chr6:97807058-98021349 bp, + strand
Genetic Position: Chr6,
45.05 cM
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MitfMi-wh/+ and MitfMi-wh/MitfMi-wh and control
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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(C57BL x DBA)F1
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Single point mutation |
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Mutation details: T to A transversion at bp 764, which leads to an isoleucine to asparagine substitution at the corresponding amino acid (212) in the encoded protein. This mutation is in the basic region of the protein. (J:19656, J:21366)
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Inheritance: | |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Combination heterozygotes of MitfMi-wh/MitfMi, MitfMi-wh/MitfMi-b, and MitfMi-wh/MitfMi-ws show some interallelic complementation in that the heterozygote of the two alleles is more nearly normal than either homozygote (J:12967, J:19656). MitfMi-b/MitfMi-wh agouti mice are light cream with white spots and ruby eyes (J:15061).
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| References |
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Original: |
J:13058
Grobman AB et al.,
"Mutant white mice. A new dominant autosomal mutant affecting coat color in Mus musculus."
J Hered 1947;38():381-384
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All: |
29 reference(s)
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Analysis Tools
