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| Nomenclature |
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Symbol:
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Hrrh
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Name:
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hairless;
rhino
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MGI ID: |
MGI:1856059 |
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Gene:
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Hr
Location:
Chr14:70552212-70573548 bp, + strand
Genetic Position: Chr14,
36.32 cM
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Hrrh/Hrrh
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Undefined |
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This allele is defined by a noncomplementation test with Hrhr.
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Rhino mice represent a genetic disorder affecting the meibomian gland structure and function. Ductal epithelial hyperkeratinization leads to plugging of the gland orifice and gland atrophy. Hyperkeratinization was not seen in the conjunctival or corneal epithelium (J:16021). Rhino mice have spleen cells with a defective response to T-dependent antigens (J:6391) and they develop an autoimmune disease characterized by hypergammaglobulinemia, immunoglobulin deposits in basement membrane of skin, spleen, liver, and kidney, and presence of antinuclear antibodies which appear in young mice and increase with age (J:6387).
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| References |
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Original: |
J:13057
Howard A,
""Rhino," an allele of hairless in the house mouse."
J Hered 1940;31():467-470
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All: |
19 reference(s)
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Analysis Tools
