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| Nomenclature |
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Symbol:
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Leprdb-3J
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Name:
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leptin receptor;
diabetes 3 Jackson
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MGI ID: |
MGI:1856012 |
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Gene:
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Lepr
Location:
Chr4:101717404-101815352 bp, + strand
Genetic Position: Chr4,
46.96 cM
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Leprdb-3J/Leprdb-3J
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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129P3/J
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Intragenic deletion |
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Mutation details: Sequence analysis of the 3J allele revealed a 17 nucleotide deletion beginning at base 1874. This deletion results in a shift of the reading frame, and a premature termination of the protein at the 11th amino acid after the deletion site. The mutation is predicted to result in a truncated receptor without a transmembrane domain and affects all Lepr splice variants. (J:40658)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:6337
Leiter EH et al.,
"A new mutation (db3J) at the diabetes locus in strain 129/J mice. I. Physiological and histological characterization."
Diabetologia 1980 Jul;19(1):58-65
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All: |
7 reference(s)
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Analysis Tools
