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| Nomenclature |
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Symbol:
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Leprdb
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Name:
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leptin receptor;
diabetes
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MGI ID: |
MGI:1856009 |
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Synonyms: |
db, db/db, Lepdb, Lepr-, leprdb, Leprdb-1J |
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Gene:
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Lepr
Location:
Chr4:101717404-101815352 bp, + strand
Genetic Position: Chr4,
46.96 cM
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Increased beta cell mass in Leprdb/Leprdb mice and Leprdb/Leprdb Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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C57BLKS/J
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Single point mutation |
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Mutation details: A G-to-T transversion in this allele created a donor splice site that causes abnormal splicing and a 106 nt insertion in the transcript, leading to premature termination of the long cellular domain of the Ob-Rb splice form and loss of its signal transducing function. (J:31324, J:31327, J:31488)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:5010
Hummel KP et al.,
"Diabetes, a new mutation in the mouse."
Science 1966 Sep 2;153(740):1127-8
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All: |
674 reference(s)
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Analysis Tools
