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| Nomenclature |
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Symbol:
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Lystbg-J
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Name:
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lysosomal trafficking regulator;
beige Jackson
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MGI ID: |
MGI:1855969 |
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Synonyms: |
bgj |
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Gene:
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Lyst
Location:
Chr13:13590409-13777440 bp, + strand
Genetic Position: Chr13,
5.28 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Intragenic deletion |
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Mutation details: This allele is defined by a noncomplementation test with Lystbg. This mutation is the result of a 3 bp deletion in exon 54 causing an isoleucine deletion at codon 3741 near the carboxy terminus of the protein. This deletion affects the WD40 domain. (J:7539, J:173521)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
This remutation occurred spontaneously in the C57BL/6J strain at The Jackson Laboratory (J:5311). It has essentially identical effects to the original Lystbg mutation, and has been used extensively in defining locus effects.
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| References |
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Original: |
J:5311
Lane PW et al.,
"Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice."
Genetics 1972 Nov;72(3):451-60
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All: |
33 reference(s)
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Analysis Tools
