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| Nomenclature |
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Symbol:
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a
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Name:
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nonagouti
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MGI ID: |
MGI:1855937 |
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Gene:
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a
Location:
Chr2:154791402-155051012 bp, + strand
Genetic Position: Chr2,
76.83 cM
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Show the 3 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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old mutant of the mouse fancy
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Viral insertion |
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Mutation details: Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host integration site is the same as for at-2Gso and Aw-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. (J:16984, J:24934)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:12970
Markert CL et al.,
"The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse."
Genetics 1956 May;41(3):429-50
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All: |
84 reference(s)
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Analysis Tools
