GO Annotations Graph

Symbol
Name
ID

Pax6
paired box gene 6
MGI:97490

Curated GO classifications for mouse, human and rat orthologs annotated from the biomedical literature.

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: mouse, human, rat, and multiple.
Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
GO annotations: Mouse from MGI; Human from GOA; Rat from RGD.
Includes only experimental evidence codes: EXP, IDA, IPI, IMP, IGI, IEP.
All nodes are linked to the MGI GO browser.
Graph is also available as SVG.
Graph generated Tue Sep 11 15:09:12 2012.

Category	GO ID	Classification Term	Gene/Product	Evidence	Organism	Reference
Molecular Function	GO:0003680	AT DNA binding	3258	IDA	Rat	RGD:632189
Molecular Function	GO:0070410	co-SMAD binding	MGI:97490	IDA	Mouse	J:172985
Molecular Function	GO:0003677	DNA binding	MGI:97490	IDA	Mouse	J:83532
Molecular Function	GO:0003690	double-stranded DNA binding	3258	IDA	Rat	RGD:632189
Molecular Function	GO:0035035	histone acetyltransferase binding	MGI:97490	IDA	Mouse	MGI:5306308
Molecular Function	GO:0071837	HMG box domain binding	MGI:97490	IPI	Mouse	J:175179
Molecular Function	GO:0005515	protein binding	MGI:97490	IPI	Mouse	J:114731
Molecular Function	GO:0005515	protein binding	UniProt:P26367	IPI	Human	PMID:16098226
Molecular Function	GO:0019901	protein kinase binding	MGI:97490	IPI	Mouse	MGI:5306308
Molecular Function	GO:0070412	R-SMAD binding	MGI:97490	IDA	Mouse	J:172985
Molecular Function	GO:0070412	R-SMAD binding	UniProt:P26367	IPI	Human	PMID:17251190
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	MGI:97490	IDA	Mouse	MGI:5306308
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	MGI:97490	IDA	Mouse	J:170025
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	UniProt:P26367	IDA	Human	PMID:20592023
Molecular Function	GO:0043565	sequence-specific DNA binding	3258	IDA	Rat	RGD:632189
Molecular Function	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	MGI:97490	IDA	Mouse	J:170025
Molecular Function	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	MGI:97490	IDA	Mouse	MGI:5306308
Molecular Function	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	UniProt:P26367	IDA	Human	PMID:20592023
Molecular Function	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:97490	IDA	Mouse	J:133921
Molecular Function	GO:0008134	transcription factor binding	MGI:97490	IPI	Mouse	MGI:5306308
Molecular Function	GO:0044212	transcription regulatory region DNA binding	MGI:97490	IDA	Mouse	J:149737
Molecular Function	GO:0031625	ubiquitin protein ligase binding	MGI:97490	IPI	Mouse	J:137611
Cellular Component	GO:0005737	cytoplasm	UniProt:E9PIX4	IDA	Human	PMID:18029348
Cellular Component	GO:0005737	cytoplasm	UniProt:P26367	IDA	Human	PMID:17291498
Cellular Component	GO:0005737	cytoplasm	UniProt:P26367	IDA	Human	PMID:18029348
Cellular Component	GO:0005622	intracellular	MGI:97490	IDA	Mouse	J:113146
Cellular Component	GO:0044424	intracellular part	MGI:97490	IDA	Mouse	J:105207
Cellular Component	GO:0044424	intracellular part	MGI:97490	IDA	Mouse	J:120581
Cellular Component	GO:0000790	nuclear chromatin	MGI:97490	IDA	Mouse	J:170025
Cellular Component	GO:0000790	nuclear chromatin	UniProt:P26367	IDA	Human	PMID:20592023
Cellular Component	GO:0005634	nucleus	MGI:97490	IDA	Mouse	J:77680
Cellular Component	GO:0005634	nucleus	MGI:97490	IDA	Mouse	J:86636
Cellular Component	GO:0005634	nucleus	MGI:97490	IDA	Mouse	J:109412
Cellular Component	GO:0005634	nucleus	MGI:97490	IDA	Mouse	J:74097
Cellular Component	GO:0005634	nucleus	MGI:97490	IDA	Mouse	J:41620
Cellular Component	GO:0005634	nucleus	MGI:97490	IDA	Mouse	J:150768
Cellular Component	GO:0005634	nucleus	UniProt:E9PIX4	IDA	Human	PMID:18029348
Cellular Component	GO:0005634	nucleus	UniProt:P26367	IDA	Human	PMID:17291498
Cellular Component	GO:0005634	nucleus	UniProt:P26367	IDA	Human	PMID:18029348
Cellular Component	GO:0005634	nucleus	3258	IDA	Rat	RGD:632189
Biological Process	GO:0009952	anterior/posterior pattern specification	MGI:97490	IMP	Mouse	J:78745
Biological Process	GO:0009952	anterior/posterior pattern specification	MGI:97490	IGI	Mouse	J:98539
Biological Process	GO:0048708	astrocyte differentiation	MGI:97490	IMP	Mouse	J:147382
Biological Process	GO:0007411	axon guidance	MGI:97490	IMP	Mouse	J:86369
Biological Process	GO:0007411	axon guidance	MGI:97490	IMP	Mouse	J:76341
Biological Process	GO:0007409	axonogenesis	MGI:97490	IMP	Mouse	J:94588
Biological Process	GO:0001568	blood vessel development	UniProt:P26367	IMP	Human	PMID:7550230
Biological Process	GO:0007420	brain development	MGI:97490	IMP	Mouse	J:54722
Biological Process	GO:0007420	brain development	MGI:97490	IMP	Mouse	J:78745
Biological Process	GO:0007420	brain development	3258	IMP	Rat	RGD:731242
Biological Process	GO:0043010	camera-type eye development	MGI:97490	IMP	Mouse	J:65765
Biological Process	GO:0043010	camera-type eye development	MGI:97490	IGI	Mouse	J:78468
Biological Process	GO:0043010	camera-type eye development	MGI:97490	IMP	Mouse	J:83532
Biological Process	GO:0043010	camera-type eye development	MGI:97490	IGI	Mouse	J:77351
Biological Process	GO:0043010	camera-type eye development	MGI:97490	IMP	Mouse	J:82632
Biological Process	GO:0043010	camera-type eye development	MGI:97490	IMP	Mouse	J:66649
Biological Process	GO:0043010	camera-type eye development	MGI:97490	IMP	Mouse	J:99962
Biological Process	GO:0030154	cell differentiation	MGI:97490	IMP	Mouse	J:92173
Biological Process	GO:0045165	cell fate commitment	MGI:97490	IGI	Mouse	J:93057
Biological Process	GO:0045165	cell fate commitment	MGI:97490	IMP	Mouse	J:99239
Biological Process	GO:0001709	cell fate determination	MGI:97490	IMP	Mouse	J:83532
Biological Process	GO:0007417	central nervous system development	3258	IEP	Rat	RGD:1578467
Biological Process	GO:0021796	cerebral cortex regionalization	MGI:97490	IMP	Mouse	J:102092
Biological Process	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain	MGI:97490	IMP	Mouse	J:66590
Biological Process	GO:0061303	cornea development in camera-type eye	UniProt:P26367	IMP	Human	PMID:7550230
Biological Process	GO:0009950	dorsal/ventral axis specification	MGI:97490	IMP	Mouse	J:58952
Biological Process	GO:0009953	dorsal/ventral pattern formation	MGI:97490	IMP	Mouse	J:94457
Biological Process	GO:0009953	dorsal/ventral pattern formation	MGI:97490	IMP	Mouse	J:99239
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	MGI:97490	IGI	Mouse	J:139006
Biological Process	GO:0042462	eye photoreceptor cell development	MGI:97490	IMP	Mouse	J:82632
Biological Process	GO:0021797	forebrain anterior/posterior pattern specification	MGI:97490	IMP	Mouse	J:41030
Biological Process	GO:0030900	forebrain development	MGI:97490	IMP	Mouse	J:94457
Biological Process	GO:0030900	forebrain development	MGI:97490	IMP	Mouse	J:94588
Biological Process	GO:0030900	forebrain development	MGI:97490	IMP	Mouse	J:98620
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	MGI:97490	IMP	Mouse	J:66590
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	MGI:97490	IMP	Mouse	J:65195
Biological Process	GO:0021905	forebrain-midbrain boundary formation	MGI:97490	IMP	Mouse	J:41030
Biological Process	GO:0042593	glucose homeostasis	UniProt:P26367	IMP	Human	PMID:11756345
Biological Process	GO:0030902	hindbrain development	3258	IDA	Rat	RGD:729590
Biological Process	GO:0061072	iris morphogenesis	UniProt:P26367	IMP	Human	PMID:7550230
Biological Process	GO:0030216	keratinocyte differentiation	MGI:97490	IMP	Mouse	J:99962
Biological Process	GO:0032808	lacrimal gland development	MGI:97490	IMP	Mouse	J:62162
Biological Process	GO:0002088	lens development in camera-type eye	MGI:97490	IMP	Mouse	J:21950
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:97490	IMP	Mouse	J:94457
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	MGI:97490	IMP	Mouse	J:99962
Biological Process	GO:0045665	negative regulation of neuron differentiation	MGI:97490	IGI	Mouse	J:112802
Biological Process	GO:0001764	neuron migration	MGI:97490	IMP	Mouse	J:98620
Biological Process	GO:0001764	neuron migration	3258	IMP	Rat	RGD:1358337
Biological Process	GO:0021778	oligodendrocyte cell fate specification	MGI:97490	IMP	Mouse	J:50974
Biological Process	GO:0021543	pallium development	MGI:97490	IMP	Mouse	J:66590
Biological Process	GO:0003322	pancreatic A cell development	MGI:97490	IMP	Mouse	J:170025
Biological Process	GO:0003322	pancreatic A cell development	UniProt:P26367	IMP	Human	PMID:20592023
Biological Process	GO:0021983	pituitary gland development	MGI:97490	IMP	Mouse	J:58952
Biological Process	GO:0042660	positive regulation of cell fate specification	3258	IMP	Rat	RGD:729590
Biological Process	GO:0030858	positive regulation of epithelial cell differentiation	MGI:97490	IMP	Mouse	J:99962
Biological Process	GO:0010628	positive regulation of gene expression	MGI:97490	IMP	Mouse	J:170025
Biological Process	GO:0010628	positive regulation of gene expression	UniProt:P26367	IMP	Human	PMID:20592023
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	MGI:97490	IMP	Mouse	J:133921
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:97490	IDA	Mouse	J:98488
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:97490	IDA	Mouse	J:133921
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:97490	IDA	Mouse	J:154645
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:97490	IDA	Mouse	MGI:5306308
Biological Process	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:97490	IDA	Mouse	J:170025
Biological Process	GO:0045893	positive regulation of transcription, DNA-dependent	UniProt:P26367	IMP	Human	PMID:20592023
Biological Process	GO:0033365	protein localization to organelle	MGI:97490	IMP	Mouse	J:103131
Biological Process	GO:0030334	regulation of cell migration	MGI:97490	IMP	Mouse	J:54722
Biological Process	GO:0050678	regulation of epithelial cell proliferation	3258	IMP	Rat	RGD:1578467
Biological Process	GO:0010468	regulation of gene expression	MGI:97490	IMP	Mouse	J:116586
Biological Process	GO:0010468	regulation of gene expression	MGI:97490	IMP	Mouse	J:142755
Biological Process	GO:0010468	regulation of gene expression	MGI:97490	IMP	Mouse	J:102092
Biological Process	GO:0050767	regulation of neurogenesis	MGI:97490	IMP	Mouse	J:94457
Biological Process	GO:0050767	regulation of neurogenesis	3258	IMP	Rat	RGD:1601222
Biological Process	GO:0045664	regulation of neuron differentiation	3258	IDA	Rat	RGD:729590
Biological Process	GO:0048505	regulation of timing of cell differentiation	MGI:97490	IMP	Mouse	J:50974
Biological Process	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:97490	IMP	Mouse	J:149737
Biological Process	GO:0021918	regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment	MGI:97490	IMP	Mouse	J:41620
Biological Process	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification	MGI:97490	IMP	Mouse	J:41620
Biological Process	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification	MGI:97490	IMP	Mouse	J:41620
Biological Process	GO:0009611	response to wounding	UniProt:P26367	IEP	Human	PMID:17982423
Biological Process	GO:0007435	salivary gland morphogenesis	MGI:97490	IMP	Mouse	J:74539
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	MGI:97490	IDA	Mouse	J:155850
Biological Process	GO:0007224	smoothened signaling pathway	MGI:97490	IDA	Mouse	J:138713
Biological Process	GO:0006366	transcription from RNA polymerase II promoter	MGI:97490	IMP	Mouse	J:170025
Biological Process	GO:0006366	transcription from RNA polymerase II promoter	UniProt:P26367	IMP	Human	PMID:20592023
Biological Process	GO:0006366	transcription from RNA polymerase II promoter	3258	IMP	Rat	RGD:1578467

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IAS Inferred from ancestral seqeuence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IKR Inferred from key residues

IMP Inferred from mutant phenotype

IMR Inferred from missing residues

IPI Inferred from physical interaction

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Obsolete Evidence Code: Not Recorded

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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