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GO Annotations Graph
 Symbol
Name
ID
Irs1
insulin receptor substrate 1
MGI:99454

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Wed Jul 23 12:17:05 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005158insulin receptor bindingISOJ:155856
Molecular FunctionGO:0005158insulin receptor bindingISOJ:164563
Molecular FunctionGO:0005159insulin-like growth factor receptor bindingISOJ:155856
Molecular FunctionGO:0005159insulin-like growth factor receptor bindingISOJ:164563
Molecular FunctionGO:0043548phosphatidylinositol 3-kinase bindingIDAJ:107119
Molecular FunctionGO:0043548phosphatidylinositol 3-kinase bindingISOJ:155856
Molecular FunctionGO:0043548phosphatidylinositol 3-kinase bindingISOJ:164563
Molecular FunctionGO:0005515protein bindingIPIJ:130473
Molecular FunctionGO:0005515protein bindingIPIJ:135557
Molecular FunctionGO:0005515protein bindingIPIJ:154728
Molecular FunctionGO:0005515protein bindingIPIJ:161178
Molecular FunctionGO:0005515protein bindingIPIJ:201303
Molecular FunctionGO:0019904protein domain specific bindingISOJ:155856
Molecular FunctionGO:0019901protein kinase bindingIDAJ:87936
Molecular FunctionGO:0019901protein kinase bindingISOJ:155856
Molecular FunctionGO:0005080protein kinase C bindingISOJ:155856
Molecular FunctionGO:0042169SH2 domain bindingISOJ:155856
Molecular FunctionGO:0004871signal transducer activityIEAJ:60000
Molecular FunctionGO:0005068transmembrane receptor protein tyrosine kinase adaptor activityISOJ:155856
Cellular ComponentGO:0005901caveolaISOJ:164563
Cellular ComponentGO:0036064ciliary basal bodyIDAJ:153289
Cellular ComponentGO:0005737cytoplasmIDAJ:84783
Cellular ComponentGO:0005829cytosolISOJ:155856
Cellular ComponentGO:0005899insulin receptor complexISOJ:155856
Cellular ComponentGO:0005622intracellularIGIJ:91846
Cellular ComponentGO:0043231intracellular membrane-bounded organelleISOJ:155856
Cellular ComponentGO:0005634nucleusIDAJ:84783
Cellular ComponentGO:0005886plasma membraneIDAJ:107119
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Biological ProcessGO:0032869cellular response to insulin stimulusIDAJ:107119
Biological ProcessGO:0032869cellular response to insulin stimulusISOJ:164563
Biological ProcessGO:0008286insulin receptor signaling pathwayISOJ:155856
Biological ProcessGO:0008286insulin receptor signaling pathwayISOJ:164563
Biological ProcessGO:0048009insulin-like growth factor receptor signaling pathwayISOJ:164563
Biological ProcessGO:0016042lipid catabolic processIMPJ:107119
Biological ProcessGO:0030879mammary gland developmentIGIJ:124667
Biological ProcessGO:0046627negative regulation of insulin receptor signaling pathwayISOJ:155856
Biological ProcessGO:0046676negative regulation of insulin secretionISOJ:155856
Biological ProcessGO:0046676negative regulation of insulin secretionISOJ:164563
Biological ProcessGO:0090275negative regulation of somatostatin secretionISOJ:155856
Biological ProcessGO:0014065phosphatidylinositol 3-kinase signalingISOJ:164563
Biological ProcessGO:0030335positive regulation of cell migrationIGIJ:124667
Biological ProcessGO:0032000positive regulation of fatty acid beta-oxidationISOJ:164563
Biological ProcessGO:0070094positive regulation of glucagon secretionISOJ:155856
Biological ProcessGO:0046326positive regulation of glucose importISOJ:164563
Biological ProcessGO:2001275positive regulation of glucose import in response to insulin stimulusISOJ:164563
Biological ProcessGO:0010907positive regulation of glucose metabolic processISOJ:164563
Biological ProcessGO:0045725positive regulation of glycogen biosynthetic processISOJ:164563
Biological ProcessGO:0046628positive regulation of insulin receptor signaling pathwayISOJ:155856
Biological ProcessGO:0002053positive regulation of mesenchymal cell proliferationIGIJ:124667
Biological ProcessGO:0043552positive regulation of phosphatidylinositol 3-kinase activityIMPJ:107119
Biological ProcessGO:0043552positive regulation of phosphatidylinositol 3-kinase activityISOJ:155856
Biological ProcessGO:0042327positive regulation of phosphorylationISOJ:155856
Biological ProcessGO:0051291protein heterooligomerizationISOJ:155856
Biological ProcessGO:0043491protein kinase B signalingIGIJ:91846
Biological ProcessGO:0034504protein localization to nucleusIDAJ:154728
Biological ProcessGO:0034504protein localization to nucleusIMPJ:154728
Biological ProcessGO:0010468regulation of gene expressionIMPJ:107119
Biological ProcessGO:0031000response to caffeineISOJ:155856
Biological ProcessGO:0032868response to insulinISOJ:164563
Biological ProcessGO:0043434response to peptide hormoneISOJ:155856
Biological ProcessGO:0007165signal transductionIEAJ:60000

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory