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GO Annotations Graph
 Symbol
Name
ID
Tgfbr1
transforming growth factor, beta receptor I
MGI:98728

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Fri Jan 17 13:56:29 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005524ATP bindingISOJ:155856
Molecular FunctionGO:0005524ATP bindingISOJ:164563
Molecular FunctionGO:0019838contributes_to
growth factor binding
ISOJ:164563
Molecular FunctionGO:0070411I-SMAD bindingISOJ:164563
Molecular FunctionGO:0016301kinase activityIEAJ:60000
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0005515protein bindingIPIJ:83727
Molecular FunctionGO:0005515protein bindingIPIJ:86237
Molecular FunctionGO:0005515protein bindingIPIJ:200401
Molecular FunctionGO:0005515protein bindingIPIJ:200409
Molecular FunctionGO:0005515protein bindingIPIJ:201272
Molecular FunctionGO:0032403protein complex bindingISOJ:155856
Molecular FunctionGO:0046982protein heterodimerization activityISOJ:155856
Molecular FunctionGO:0004672protein kinase activityISOJ:164563
Molecular FunctionGO:0004674protein serine/threonine kinase activityISOJ:155856
Molecular FunctionGO:0004674protein serine/threonine kinase activityISOJ:164563
Molecular FunctionGO:0046332SMAD bindingIDAJ:83727
Molecular FunctionGO:0046332SMAD bindingISOJ:164563
Molecular FunctionGO:0016740transferase activityIEAJ:60000
Molecular FunctionGO:0016772transferase activity, transferring phosphorus-containing groupsIEAJ:72247
Molecular FunctionGO:0050431transforming growth factor beta bindingIPIJ:128350
Molecular FunctionGO:0050431transforming growth factor beta bindingISOJ:155856
Molecular FunctionGO:0050431transforming growth factor beta bindingISOJ:164563
Molecular FunctionGO:0050431contributes_to
transforming growth factor beta binding
ISOJ:164563
Molecular FunctionGO:0005025transforming growth factor beta receptor activity, type IISOJ:155856
Molecular FunctionGO:0005025transforming growth factor beta receptor activity, type IISOJ:164563
Molecular FunctionGO:0005024transforming growth factor beta-activated receptor activityIDAJ:97303
Molecular FunctionGO:0005024transforming growth factor beta-activated receptor activityIGIJ:128350
Molecular FunctionGO:0005024contributes_to
transforming growth factor beta-activated receptor activity
ISOJ:164563
Molecular FunctionGO:0005024transforming growth factor beta-activated receptor activityISOJ:164563
Molecular FunctionGO:0004675transmembrane receptor protein serine/threonine kinase activityISOJ:164563
Molecular FunctionGO:0005114type II transforming growth factor beta receptor bindingISOJ:164563
Molecular FunctionGO:0031625ubiquitin protein ligase bindingISOJ:155856
Cellular ComponentGO:0016324apical plasma membraneISOJ:155856
Cellular ComponentGO:0016323basolateral plasma membraneISOJ:155856
Cellular ComponentGO:0005901caveolaISOJ:128350
Cellular ComponentGO:0030054cell junctionIEAJ:60000
Cellular ComponentGO:0016021integral component of membraneIEAJ:60000
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0016020membraneIEAJ:72247
Cellular ComponentGO:0045121membrane raftISOJ:128350
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0043234protein complexISOJ:155856
Cellular ComponentGO:0043235receptor complexISOJ:164563
Cellular ComponentGO:0005923tight junctionISOJ:164563
Biological ProcessGO:0000186activation of MAPKK activityISOJ:164563
Biological ProcessGO:0001525angiogenesisIMPJ:68770
Biological ProcessGO:0009952anterior/posterior pattern specificationIGIJ:116889
Biological ProcessGO:0006915apoptotic processIEAJ:60000
Biological ProcessGO:0048844artery morphogenesisIMPJ:119667
Biological ProcessGO:0001824blastocyst developmentIDAJ:51778
Biological ProcessGO:0030154cell differentiationIEAJ:60000
Biological ProcessGO:0048870cell motilityISOJ:164563
Biological ProcessGO:0071560cellular response to transforming growth factor beta stimulusIDAJ:149284
Biological ProcessGO:0071560cellular response to transforming growth factor beta stimulusISOJ:164563
Biological ProcessGO:0030199collagen fibril organizationIMPJ:100586
Biological ProcessGO:0009790embryo developmentIMPJ:87407
Biological ProcessGO:0009790embryo developmentIMPJ:104918
Biological ProcessGO:0048701embryonic cranial skeleton morphogenesisIMPJ:119289
Biological ProcessGO:0043542endothelial cell migrationIMPJ:68770
Biological ProcessGO:0001837epithelial to mesenchymal transitionISOJ:164563
Biological ProcessGO:0008354germ cell migrationIMPJ:100586
Biological ProcessGO:0007507heart developmentIMPJ:119667
Biological ProcessGO:0001701in utero embryonic developmentIMPJ:68770
Biological ProcessGO:0001701in utero embryonic developmentIMPJ:87407
Biological ProcessGO:0001701in utero embryonic developmentIMPJ:119667
Biological ProcessGO:0001822kidney developmentIGIJ:116889
Biological ProcessGO:0002088lens development in camera-type eyeIMPJ:71882
Biological ProcessGO:0043066negative regulation of apoptotic processIMPJ:119289
Biological ProcessGO:0043066negative regulation of apoptotic processIMPJ:119667
Biological ProcessGO:0032331negative regulation of chondrocyte differentiationIMPJ:149284
Biological ProcessGO:0045602negative regulation of endothelial cell differentiationISOJ:155856
Biological ProcessGO:0001937negative regulation of endothelial cell proliferationIGIJ:178359
Biological ProcessGO:2001237negative regulation of extrinsic apoptotic signaling pathwayISOJ:164563
Biological ProcessGO:0048663neuron fate commitmentIMPJ:100384
Biological ProcessGO:0060021palate developmentIGIJ:116889
Biological ProcessGO:0060021palate developmentIMPJ:119289
Biological ProcessGO:0060017parathyroid gland developmentIMPJ:119667
Biological ProcessGO:0060389pathway-restricted SMAD protein phosphorylationISOJ:164563
Biological ProcessGO:0018105peptidyl-serine phosphorylationISOJ:164563
Biological ProcessGO:0018107peptidyl-threonine phosphorylationISOJ:164563
Biological ProcessGO:0060037pharyngeal system developmentIMPJ:119667
Biological ProcessGO:0016310phosphorylationIEAJ:60000
Biological ProcessGO:2001235positive regulation of apoptotic signaling pathwayISOJ:164563
Biological ProcessGO:0030307positive regulation of cell growthISOJ:164563
Biological ProcessGO:0008284positive regulation of cell proliferationISOJ:164563
Biological ProcessGO:0051272positive regulation of cellular component movementISOJ:164563
Biological ProcessGO:0051491positive regulation of filopodium assemblyIMPJ:119289
Biological ProcessGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylationISOJ:164563
Biological ProcessGO:0051897positive regulation of protein kinase B signalingISOJ:164563
Biological ProcessGO:0060391positive regulation of SMAD protein import into nucleusISOJ:164563
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedISOJ:164563
Biological ProcessGO:0009791post-embryonic developmentIMPJ:119289
Biological ProcessGO:0046777protein autophosphorylationISOJ:155856
Biological ProcessGO:0006468protein phosphorylationIGIJ:128350
Biological ProcessGO:0006468protein phosphorylationISOJ:155856
Biological ProcessGO:0006468protein phosphorylationISOJ:164563
Biological ProcessGO:0010468regulation of gene expressionIMPJ:119289
Biological ProcessGO:0040008regulation of growthIEAJ:60000
Biological ProcessGO:0043393regulation of protein bindingIMPJ:109361
Biological ProcessGO:0031396regulation of protein ubiquitinationISOJ:164563
Biological ProcessGO:0006355regulation of transcription, DNA-templatedISOJ:164563
Biological ProcessGO:0070723response to cholesterolIDAJ:128350
Biological ProcessGO:0070723response to cholesterolISOJ:164563
Biological ProcessGO:0043627response to estrogenISOJ:155856
Biological ProcessGO:0007165signal transductionISOJ:164563
Biological ProcessGO:0001501skeletal system developmentIGIJ:116889
Biological ProcessGO:0048705skeletal system morphogenesisIGIJ:116889
Biological ProcessGO:0048538thymus developmentIMPJ:119667
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayIMPJ:68770
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayIDAJ:86237
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayIDAJ:97303
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayIMPJ:119667
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayISOJ:155856
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayISOJ:164563
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayIMPJ:178359
Biological ProcessGO:0007178transmembrane receptor protein serine/threonine kinase signaling pathwayIGIJ:128350

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory