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GO Annotations Graph
 Symbol
Name
ID
Notch1
notch 1
MGI:97363

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Wed Jul 23 12:17:05 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005509calcium ion bindingIEAJ:72247
Molecular FunctionGO:0003682chromatin bindingIDAJ:97176
Molecular FunctionGO:0031490chromatin DNA bindingIDAJ:123632
Molecular FunctionGO:0001047core promoter bindingIDAJ:166398
Molecular FunctionGO:0019899enzyme bindingIPIJ:183220
Molecular FunctionGO:0019899enzyme bindingIPIJ:183961
Molecular FunctionGO:0004857enzyme inhibitor activityIDAJ:183220
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0005515protein bindingIPIJ:34426
Molecular FunctionGO:0005515protein bindingIPIJ:42994
Molecular FunctionGO:0005515protein bindingIPIJ:58381
Molecular FunctionGO:0005515protein bindingIPIJ:88030
Molecular FunctionGO:0005515protein bindingIPIJ:97329
Molecular FunctionGO:0005515protein bindingIPIJ:166398
Molecular FunctionGO:0005515protein bindingIPIJ:181926
Molecular FunctionGO:0005515protein bindingIPIJ:200507
Molecular FunctionGO:0004872receptor activityIEAJ:72247
Molecular FunctionGO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptionIDAJ:119151
Molecular FunctionGO:0043565sequence-specific DNA bindingIDAJ:123632
Molecular FunctionGO:0003700sequence-specific DNA binding transcription factor activityIDAJ:40289
Molecular FunctionGO:0003700sequence-specific DNA binding transcription factor activityIDAJ:123632
Cellular ComponentGO:0001669acrosomal vesicleISOJ:155856
Cellular ComponentGO:0005623cellIGIJ:123631
Cellular ComponentGO:0071944cell peripheryIDAJ:195630
Cellular ComponentGO:0009986cell surfaceIDAJ:97329
Cellular ComponentGO:0005737cytoplasmIDAJ:99826
Cellular ComponentGO:0005794Golgi apparatusISOJ:155856
Cellular ComponentGO:0016021integral component of membraneIEAJ:60000
Cellular ComponentGO:0016021integral component of membraneIEAJ:72247
Cellular ComponentGO:0005887integral component of plasma membraneICJ:58381
Cellular ComponentGO:0002193MAML1-RBP-Jkappa- ICN1 complexISOJ:164563
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0016020membraneIEAJ:72247
Cellular ComponentGO:0005634nucleusIDAJ:54336
Cellular ComponentGO:0005634nucleusIDAJ:104840
Cellular ComponentGO:0005634nucleusIDAJ:108824
Cellular ComponentGO:0005634nucleusIDAJ:114702
Cellular ComponentGO:0005634nucleusIDAJ:119151
Cellular ComponentGO:0005634nucleusIDAJ:124179
Cellular ComponentGO:0005634nucleusISOJ:155856
Cellular ComponentGO:0005634nucleusIMPJ:170885
Cellular ComponentGO:0005634nucleusIDAJ:183961
Cellular ComponentGO:0005886plasma membraneIDAJ:114702
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Cellular ComponentGO:0043235receptor complexISOJ:194542
Biological ProcessGO:0042640anagenIMPJ:100563
Biological ProcessGO:0001525angiogenesisIEAJ:60000
Biological ProcessGO:0003180aortic valve morphogenesisISOJ:164563
Biological ProcessGO:1902263apoptotic process involved in embryonic digit morphogenesisIMPJ:102852
Biological ProcessGO:0060842arterial endothelial cell differentiationIMPJ:89444
Biological ProcessGO:0048708astrocyte differentiationISOJ:155856
Biological ProcessGO:0003162atrioventricular node developmentIMPJ:171825
Biological ProcessGO:0003181atrioventricular valve morphogenesisIMPJ:87765
Biological ProcessGO:0003181atrioventricular valve morphogenesisIMPJ:171825
Biological ProcessGO:0009912auditory receptor cell fate commitmentIMPJ:144981
Biological ProcessGO:0007409axonogenesisIDAJ:95688
Biological ProcessGO:0007409axonogenesisIMPJ:101735
Biological ProcessGO:0048754branching morphogenesis of an epithelial tubeIMPJ:96080
Biological ProcessGO:0003209cardiac atrium morphogenesisIMPJ:165329
Biological ProcessGO:0003207cardiac chamber formationIMPJ:165329
Biological ProcessGO:0060317cardiac epithelial to mesenchymal transitionIMPJ:133699
Biological ProcessGO:0003214cardiac left ventricle morphogenesisIMPJ:165329
Biological ProcessGO:0060038cardiac muscle cell proliferationIMPJ:178290
Biological ProcessGO:0055008cardiac muscle tissue morphogenesisIMPJ:170885
Biological ProcessGO:0003213cardiac right atrium morphogenesisIMPJ:170885
Biological ProcessGO:0003219cardiac right ventricle formationIMPJ:158135
Biological ProcessGO:0060411cardiac septum morphogenesisIMPJ:170885
Biological ProcessGO:0060948cardiac vascular smooth muscle cell developmentIMPJ:178290
Biological ProcessGO:0003208cardiac ventricle morphogenesisIMPJ:178290
Biological ProcessGO:0030154cell differentiationIMPJ:78726
Biological ProcessGO:0030154cell differentiationIMPJ:86975
Biological ProcessGO:0045165cell fate commitmentIMPJ:101154
Biological ProcessGO:0001708cell fate specificationIMPJ:90057
Biological ProcessGO:0003273cell migration involved in endocardial cushion formationIMPJ:165329
Biological ProcessGO:0071372cellular response to follicle-stimulating hormone stimulusISOJ:164563
Biological ProcessGO:0035924cellular response to vascular endothelial growth factor stimulusISOJ:164563
Biological ProcessGO:0007386compartment pattern specificationIMPJ:77247
Biological ProcessGO:0060982coronary artery morphogenesisIMPJ:178290
Biological ProcessGO:0003169coronary vein morphogenesisIMPJ:178290
Biological ProcessGO:0007368determination of left/right symmetryIMPJ:25248
Biological ProcessGO:0007368determination of left/right symmetryIMPJ:83358
Biological ProcessGO:0035116embryonic hindlimb morphogenesisIMPJ:102852
Biological ProcessGO:0030326embryonic limb morphogenesisIGIJ:103603
Biological ProcessGO:0060956endocardial cell differentiationIMPJ:165329
Biological ProcessGO:0003203endocardial cushion morphogenesisIMPJ:87765
Biological ProcessGO:0003157endocardium developmentIMPJ:119151
Biological ProcessGO:0003160endocardium morphogenesisIMPJ:165329
Biological ProcessGO:0007492endoderm developmentIMPJ:86975
Biological ProcessGO:0008544epidermis developmentIGIJ:94517
Biological ProcessGO:0001837epithelial to mesenchymal transitionIMPJ:87765
Biological ProcessGO:0003198epithelial to mesenchymal transition involved in endocardial cushion formationIMPJ:87765
Biological ProcessGO:0030900forebrain developmentIMPJ:101735
Biological ProcessGO:0030900forebrain developmentIGIJ:101735
Biological ProcessGO:0007440foregut morphogenesisIMPJ:101154
Biological ProcessGO:0010001glial cell differentiationIMPJ:99826
Biological ProcessGO:0003241growth involved in heart morphogenesisIMPJ:170885
Biological ProcessGO:0031069hair follicle morphogenesisIMPJ:94517
Biological ProcessGO:0031069hair follicle morphogenesisIMPJ:100563
Biological ProcessGO:0007507heart developmentIMPJ:87765
Biological ProcessGO:0007507heart developmentISOJ:164563
Biological ProcessGO:0001947heart loopingIGIJ:83358
Biological ProcessGO:0061384heart trabecula morphogenesisIMPJ:165329
Biological ProcessGO:0006959humoral immune responseIGIJ:123631
Biological ProcessGO:0001701in utero embryonic developmentIMPJ:25248
Biological ProcessGO:0002437inflammatory response to antigenic stimulusIGIJ:123631
Biological ProcessGO:0072602interleukin-4 secretionIGIJ:123631
Biological ProcessGO:0030216keratinocyte differentiationIMPJ:90057
Biological ProcessGO:0070986left/right axis specificationIGIJ:83358
Biological ProcessGO:0001889liver developmentIMPJ:91008
Biological ProcessGO:0030324lung developmentIMPJ:96080
Biological ProcessGO:0014031mesenchymal cell developmentIMPJ:133699
Biological ProcessGO:0003192mitral valve formationISOJ:164563
Biological ProcessGO:0007275multicellular organismal developmentIEAJ:60000
Biological ProcessGO:0007275multicellular organismal developmentIEAJ:72247
Biological ProcessGO:2000811negative regulation of anoikisISOJ:164563
Biological ProcessGO:0030514negative regulation of BMP signaling pathwayIMPJ:155019
Biological ProcessGO:0045955negative regulation of calcium ion-dependent exocytosisIMPJ:147579
Biological ProcessGO:0090090negative regulation of canonical Wnt signaling pathwayIMPJ:158135
Biological ProcessGO:0043086negative regulation of catalytic activityIDAJ:183220
Biological ProcessGO:0060548negative regulation of cell deathIMPJ:25248
Biological ProcessGO:0045596negative regulation of cell differentiationIMPJ:96080
Biological ProcessGO:0090051negative regulation of cell migration involved in sprouting angiogenesisISOJ:164563
Biological ProcessGO:0008285negative regulation of cell proliferationISOJ:164563
Biological ProcessGO:0010812negative regulation of cell-substrate adhesionISOJ:164563
Biological ProcessGO:2001027negative regulation of endothelial cell chemotaxisISOJ:164563
Biological ProcessGO:0060253negative regulation of glial cell proliferationIDAJ:82774
Biological ProcessGO:0045662negative regulation of myoblast differentiationISOJ:164563
Biological ProcessGO:0010832negative regulation of myotube differentiationIDAJ:183961
Biological ProcessGO:0050768negative regulation of neurogenesisIDAJ:183961
Biological ProcessGO:0045665negative regulation of neuron differentiationIGIJ:54662
Biological ProcessGO:0045665negative regulation of neuron differentiationIMPJ:101735
Biological ProcessGO:0045665negative regulation of neuron differentiationISOJ:155856
Biological ProcessGO:0048715negative regulation of oligodendrocyte differentiationIDAJ:82774
Biological ProcessGO:0030279negative regulation of ossificationIMPJ:187551
Biological ProcessGO:0045668negative regulation of osteoblast differentiationIMPJ:155019
Biological ProcessGO:0046533negative regulation of photoreceptor cell differentiationIMPJ:105970
Biological ProcessGO:2000974negative regulation of pro-B cell differentiationIMPJ:183977
Biological ProcessGO:2000737negative regulation of stem cell differentiationISOJ:164563
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterIMPJ:87765
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterIMPJ:101495
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterIMPJ:165329
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterIDAJ:183977
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedIDAJ:101495
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedIMPJ:155019
Biological ProcessGO:0021915neural tube developmentIMPJ:25248
Biological ProcessGO:0030182neuron differentiationIMPJ:39351
Biological ProcessGO:0048663neuron fate commitmentIGIJ:101735
Biological ProcessGO:0061314Notch signaling involved in heart developmentIMPJ:87765
Biological ProcessGO:0061314Notch signaling involved in heart developmentISOJ:164563
Biological ProcessGO:0061314Notch signaling involved in heart developmentIGIJ:165329
Biological ProcessGO:0061314Notch signaling involved in heart developmentIMPJ:170885
Biological ProcessGO:0007219Notch signaling pathwayICJ:58381
Biological ProcessGO:0007219Notch signaling pathwayIMPJ:144981
Biological ProcessGO:0007219Notch signaling pathwayISOJ:155856
Biological ProcessGO:0007219Notch signaling pathwayISOJ:164563
Biological ProcessGO:0007219Notch signaling pathwayIDAJ:175008
Biological ProcessGO:0003270Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferationIMPJ:158135
Biological ProcessGO:0002051osteoblast fate commitmentNASJ:101495
Biological ProcessGO:0003344pericardium morphogenesisIMPJ:87765
Biological ProcessGO:0003344pericardium morphogenesisIMPJ:165329
Biological ProcessGO:0003344pericardium morphogenesisIMPJ:178290
Biological ProcessGO:0043065positive regulation of apoptotic processIDAJ:90392
Biological ProcessGO:0043065positive regulation of apoptotic processIGIJ:103603
Biological ProcessGO:0048711positive regulation of astrocyte differentiationIDAJ:82774
Biological ProcessGO:0030513positive regulation of BMP signaling pathwayIDAJ:166398
Biological ProcessGO:0060045positive regulation of cardiac muscle cell proliferationIMPJ:170885
Biological ProcessGO:0030335positive regulation of cell migrationIMPJ:165329
Biological ProcessGO:0008284positive regulation of cell proliferationIGIJ:94813
Biological ProcessGO:0008284positive regulation of cell proliferationISOJ:164563
Biological ProcessGO:0045603positive regulation of endothelial cell differentiationISOJ:155856
Biological ProcessGO:1901189positive regulation of ephrin receptor signaling pathwayICJ:119151
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationIGIJ:147579
Biological ProcessGO:0010718positive regulation of epithelial to mesenchymal transitionISOJ:164563
Biological ProcessGO:0010718positive regulation of epithelial to mesenchymal transitionIMPJ:165329
Biological ProcessGO:0045687positive regulation of glial cell differentiationISOJ:155856
Biological ProcessGO:0046427positive regulation of JAK-STAT cascadeIDAJ:175195
Biological ProcessGO:0045618positive regulation of keratinocyte differentiationIGIJ:108327
Biological ProcessGO:0045618positive regulation of keratinocyte differentiationIDAJ:114702
Biological ProcessGO:0002052positive regulation of neuroblast proliferationISOJ:155856
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:83945
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIMPJ:87765
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIMPJ:89444
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:98581
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIMPJ:101495
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:102280
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIGIJ:108327
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:108327
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIMPJ:119151
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:123632
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIMPJ:133699
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterISOJ:155856
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterISOJ:164563
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIMPJ:170885
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIMPJ:178290
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:184125
Biological ProcessGO:0061419positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaIDAJ:183961
Biological ProcessGO:0007221positive regulation of transcription of Notch receptor targetIGIJ:83687
Biological ProcessGO:0007221positive regulation of transcription of Notch receptor targetISOJ:155856
Biological ProcessGO:0007221positive regulation of transcription of Notch receptor targetIGIJ:197487
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIDAJ:40289
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIDAJ:82774
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIDAJ:166398
Biological ProcessGO:0060740prostate gland epithelium morphogenesisIMPJ:104805
Biological ProcessGO:0003184pulmonary valve morphogenesisISOJ:164563
Biological ProcessGO:0003264regulation of cardioblast proliferationISOJ:155856
Biological ProcessGO:0061344regulation of cell adhesion involved in heart morphogenesisICJ:87765
Biological ProcessGO:0030334regulation of cell migrationIMPJ:165329
Biological ProcessGO:0042127regulation of cell proliferationISOJ:155856
Biological ProcessGO:0050793regulation of developmental processIEAJ:72247
Biological ProcessGO:0050678regulation of epithelial cell proliferationIMPJ:101154
Biological ProcessGO:0060768regulation of epithelial cell proliferation involved in prostate gland developmentIMPJ:104805
Biological ProcessGO:1901201regulation of extracellular matrix assemblyIMPJ:178290
Biological ProcessGO:0010468regulation of gene expressionIMPJ:39351
Biological ProcessGO:0050767regulation of neurogenesisIMPJ:39351
Biological ProcessGO:0014807regulation of somitogenesisIMPJ:25248
Biological ProcessGO:0006357regulation of transcription from RNA polymerase II promoterIGIJ:97176
Biological ProcessGO:0003256regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationIMPJ:170885
Biological ProcessGO:0006355regulation of transcription, DNA-templatedIEAJ:60000
Biological ProcessGO:0006355regulation of transcription, DNA-templatedIEAJ:72247
Biological ProcessGO:0032495response to muramyl dipeptideIDAJ:170396
Biological ProcessGO:0060528secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus developmentIMPJ:104805
Biological ProcessGO:0035914skeletal muscle cell differentiationIMPJ:178918
Biological ProcessGO:0048103somatic stem cell divisionIDAJ:83550
Biological ProcessGO:0048103somatic stem cell divisionIGIJ:94813
Biological ProcessGO:0007283spermatogenesisISOJ:155856
Biological ProcessGO:0002040sprouting angiogenesisIMPJ:100449
Biological ProcessGO:0006366transcription from RNA polymerase II promoterIDAJ:119151
Biological ProcessGO:0006351transcription, DNA-templatedIEAJ:60000
Biological ProcessGO:0035148tube formationISOJ:164563
Biological ProcessGO:0060979vasculogenesis involved in coronary vascular morphogenesisIMPJ:178290
Biological ProcessGO:0060843venous endothelial cell differentiationIMPJ:165329
Biological ProcessGO:0060412ventricular septum morphogenesisISOJ:164563
Biological ProcessGO:0003222ventricular trabecula myocardium morphogenesisIMPJ:119151

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory