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GO Annotations Graph
 Symbol
Name
ID
Ins2
insulin II
MGI:96573

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Wed Jul 23 12:17:05 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005179hormone activityISOJ:164563
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0005158insulin receptor bindingISOJ:164563
Molecular FunctionGO:0005159insulin-like growth factor receptor bindingISOJ:164563
Molecular FunctionGO:0002020protease bindingISOJ:155856
Molecular FunctionGO:0002020protease bindingISOJ:164563
Molecular FunctionGO:0032403protein complex bindingISOJ:155856
Cellular ComponentGO:0005737cytoplasmIDAJ:105207
Cellular ComponentGO:0005576extracellular regionIEAJ:60000
Cellular ComponentGO:0005576extracellular regionIEAJ:72247
Cellular ComponentGO:0005615extracellular spaceISOJ:155856
Cellular ComponentGO:0005615extracellular spaceISOJ:164563
Cellular ComponentGO:0005622intracellularIMPJ:74700
Cellular ComponentGO:0005634nucleusIDAJ:80826
Cellular ComponentGO:0030141secretory granuleIDAJ:100746
Cellular ComponentGO:0030141colocalizes_with
secretory granule
ISOJ:155856
Cellular ComponentGO:0030141secretory granuleISOJ:155856
Cellular ComponentGO:0005732small nucleolar ribonucleoprotein complexIDAJ:80826
Biological ProcessGO:0000187activation of MAPK activityIDAJ:79150
Biological ProcessGO:0032148activation of protein kinase B activityISOJ:164563
Biological ProcessGO:0006953acute-phase responseISOJ:164563
Biological ProcessGO:0046631alpha-beta T cell activationISOJ:164563
Biological ProcessGO:0060070canonical Wnt signaling pathwayIGIJ:95052
Biological ProcessGO:0005975carbohydrate metabolic processIEAJ:60000
Biological ProcessGO:0006983ER overload responseIMPJ:74700
Biological ProcessGO:0055089fatty acid homeostasisISOJ:164563
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayISOJ:164563
Biological ProcessGO:0042593glucose homeostasisISOJ:164563
Biological ProcessGO:0006006glucose metabolic processIMPJ:74700
Biological ProcessGO:0015758glucose transportTASJ:79240
Biological ProcessGO:0015758glucose transportISOJ:164563
Biological ProcessGO:0008286insulin receptor signaling pathwayIDAJ:83950
Biological ProcessGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIMPJ:74700
Biological ProcessGO:0016042lipid catabolic processIDAJ:83950
Biological ProcessGO:0000165MAPK cascadeISOJ:164563
Biological ProcessGO:0007520myoblast fusionIGIJ:95052
Biological ProcessGO:0007520myoblast fusionIGIJ:95052
Biological ProcessGO:0014902myotube differentiationIGIJ:95052
Biological ProcessGO:0014902myotube differentiationIGIJ:95052
Biological ProcessGO:0002674negative regulation of acute inflammatory responseISOJ:164563
Biological ProcessGO:0045922negative regulation of fatty acid metabolic processISOJ:164563
Biological ProcessGO:2000252negative regulation of feeding behaviorISOJ:164563
Biological ProcessGO:0045818negative regulation of glycogen catabolic processISOJ:164563
Biological ProcessGO:0033861negative regulation of NAD(P)H oxidase activityISOJ:164563
Biological ProcessGO:0042177negative regulation of protein catabolic processISOJ:164563
Biological ProcessGO:0032460negative regulation of protein oligomerizationISOJ:164563
Biological ProcessGO:0050709negative regulation of protein secretionISOJ:164563
Biological ProcessGO:0045861negative regulation of proteolysisISOJ:164563
Biological ProcessGO:0060266negative regulation of respiratory burst involved in inflammatory responseISOJ:164563
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterIDAJ:49085
Biological ProcessGO:0008284positive regulation of cell proliferationISOJ:164563
Biological ProcessGO:0032270positive regulation of cellular protein metabolic processISOJ:164563
Biological ProcessGO:0050715positive regulation of cytokine secretionISOJ:164563
Biological ProcessGO:0045740positive regulation of DNA replicationISOJ:164563
Biological ProcessGO:0046326positive regulation of glucose importISOJ:164563
Biological ProcessGO:0045725positive regulation of glycogen biosynthetic processISOJ:164563
Biological ProcessGO:0045821positive regulation of glycolytic processISOJ:164563
Biological ProcessGO:0046628positive regulation of insulin receptor signaling pathwayISOJ:164563
Biological ProcessGO:0043410positive regulation of MAPK cascadeISOJ:164563
Biological ProcessGO:0045840positive regulation of mitosisISOJ:164563
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityISOJ:164563
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationISOJ:164563
Biological ProcessGO:0043552positive regulation of phosphatidylinositol 3-kinase activityIDAJ:107119
Biological ProcessGO:0014068positive regulation of phosphatidylinositol 3-kinase signalingISOJ:164563
Biological ProcessGO:0051897positive regulation of protein kinase B signalingISOJ:164563
Biological ProcessGO:0060267positive regulation of respiratory burstISOJ:164563
Biological ProcessGO:0006521regulation of cellular amino acid metabolic processISOJ:164563
Biological ProcessGO:0010468regulation of gene expressionIDAJ:149618
Biological ProcessGO:0042325regulation of phosphorylationIDAJ:79150
Biological ProcessGO:0043393regulation of protein bindingIDAJ:46536
Biological ProcessGO:0032880regulation of protein localizationISOJ:164563
Biological ProcessGO:0050708regulation of protein secretionISOJ:164563
Biological ProcessGO:0022898regulation of transmembrane transporter activityISOJ:164563
Biological ProcessGO:0042060wound healingISOJ:164563

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory