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GO Annotations Graph
 Symbol
Name
ID
Shank3
SH3/ankyrin domain gene 3
MGI:1930016

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Wed Jul 23 12:17:05 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0003779actin bindingIEAJ:60000
Molecular FunctionGO:0030160GKAP/Homer scaffold activityISOJ:155856
Molecular FunctionGO:0042802identical protein bindingISOJ:155856
Molecular FunctionGO:0035255ionotropic glutamate receptor bindingIPIJ:108736
Molecular FunctionGO:0035255ionotropic glutamate receptor bindingIPIJ:150922
Molecular FunctionGO:0005515protein bindingIPIJ:94527
Molecular FunctionGO:0008022protein C-terminus bindingIPIJ:108736
Molecular FunctionGO:0008022protein C-terminus bindingISOJ:155856
Molecular FunctionGO:0043621protein self-associationISOJ:155856
Molecular FunctionGO:0097110scaffold protein bindingIPIJ:108736
Molecular FunctionGO:0097110scaffold protein bindingISOJ:155856
Molecular FunctionGO:0017124SH3 domain bindingISOJ:155856
Molecular FunctionGO:0008270zinc ion bindingISOJ:155856
Cellular ComponentGO:0030054cell junctionIEAJ:60000
Cellular ComponentGO:0042995cell projectionIEAJ:60000
Cellular ComponentGO:0060170ciliary membraneISOJ:155856
Cellular ComponentGO:0005737cytoplasmIEAJ:60000
Cellular ComponentGO:0060076excitatory synapseICJ:171113
Cellular ComponentGO:0005622intracellularIGIJ:94527
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0043005neuron projectionIDAJ:184110
Cellular ComponentGO:0044309neuron spineIDAJ:108736
Cellular ComponentGO:0097481neuronal postsynaptic densityISOJ:155856
Cellular ComponentGO:0005886plasma membraneIDAJ:108736
Cellular ComponentGO:0014069postsynaptic densityISOJ:155856
Cellular ComponentGO:0045211postsynaptic membraneIEAJ:60000
Cellular ComponentGO:0045202synapseISOJ:155856
Biological ProcessGO:0030534adult behaviorISOJ:164563
Biological ProcessGO:0097113alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clusteringIMPJ:173402
Biological ProcessGO:0097113alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clusteringIMPJ:184110
Biological ProcessGO:0048854brain morphogenesisIMPJ:171113
Biological ProcessGO:0060997dendritic spine morphogenesisIMPJ:171113
Biological ProcessGO:0060997dendritic spine morphogenesisIMPJ:173402
Biological ProcessGO:0060997dendritic spine morphogenesisIMPJ:175320
Biological ProcessGO:0001838embryonic epithelial tube formationIGIJ:94527
Biological ProcessGO:0097117guanylate kinase-associated protein clusteringIMPJ:173402
Biological ProcessGO:0007612learningISOJ:164563
Biological ProcessGO:0007612learningIMPJ:173402
Biological ProcessGO:0035641locomotory exploration behaviorIMPJ:171113
Biological ProcessGO:0035641locomotory exploration behaviorIMPJ:173402
Biological ProcessGO:0000165MAPK cascadeIGIJ:94527
Biological ProcessGO:0007613memoryIMPJ:173402
Biological ProcessGO:0097114N-methyl-D-aspartate receptor clusteringIMPJ:173402
Biological ProcessGO:0032232negative regulation of actin filament bundle assemblyIDAJ:148808
Biological ProcessGO:0045794negative regulation of cell volumeIMPJ:171113
Biological ProcessGO:0050885neuromuscular process controlling balanceIMPJ:173402
Biological ProcessGO:2000969positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityIMPJ:171113
Biological ProcessGO:0060999positive regulation of dendritic spine developmentIMPJ:184110
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic membrane potentialIMPJ:171113
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic membrane potentialIMPJ:175320
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic membrane potentialIMPJ:184110
Biological ProcessGO:1900451positive regulation of glutamate receptor signaling pathwayISOJ:155856
Biological ProcessGO:1900451positive regulation of glutamate receptor signaling pathwayIMPJ:184110
Biological ProcessGO:0048170positive regulation of long-term neuronal synaptic plasticityIMPJ:175320
Biological ProcessGO:0051835positive regulation of synapse structural plasticityIMPJ:175320
Biological ProcessGO:0051968positive regulation of synaptic transmission, glutamatergicIMPJ:171113
Biological ProcessGO:0051968positive regulation of synaptic transmission, glutamatergicIMPJ:175320
Biological ProcessGO:0051968positive regulation of synaptic transmission, glutamatergicIMPJ:184110
Biological ProcessGO:0097107postsynaptic density assemblyIMPJ:171113
Biological ProcessGO:0051259protein oligomerizationISOJ:155856
Biological ProcessGO:2000822regulation of behavioral fear responseIMPJ:171113
Biological ProcessGO:0061001regulation of dendritic spine morphogenesisIMPJ:184110
Biological ProcessGO:2000821regulation of grooming behaviorIMPJ:171113
Biological ProcessGO:2000821regulation of grooming behaviorIMPJ:173402
Biological ProcessGO:1900452regulation of long term synaptic depressionIMPJ:184110
Biological ProcessGO:1900271regulation of long-term synaptic potentiationIMPJ:173402
Biological ProcessGO:0035176social behaviorISOJ:164563
Biological ProcessGO:0035176social behaviorIMPJ:171113
Biological ProcessGO:0035176social behaviorIMPJ:173402
Biological ProcessGO:0035176social behaviorIMPJ:175320
Biological ProcessGO:0021773striatal medium spiny neuron differentiationIMPJ:171113
Biological ProcessGO:0007416synapse assemblyIMPJ:171113
Biological ProcessGO:0042297vocal learningISOJ:164563
Biological ProcessGO:0071625vocalization behaviorISOJ:164563
Biological ProcessGO:0071625vocalization behaviorIMPJ:173402
Biological ProcessGO:0071625vocalization behaviorIMPJ:175320

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory