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GO Annotations Graph
 Symbol
Name
ID
Lrrk2
leucine-rich repeat kinase 2
MGI:1913975

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Fri Jan 17 13:56:29 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005524ATP bindingIEAJ:60000
Molecular FunctionGO:0005524ATP bindingIEAJ:72247
Molecular FunctionGO:0005525GTP bindingISAJ:113152
Molecular FunctionGO:0005525GTP bindingISOJ:164563
Molecular FunctionGO:0034211GTP-dependent protein kinase activityISAJ:113152
Molecular FunctionGO:0034211GTP-dependent protein kinase activityISOJ:164563
Molecular FunctionGO:0005096GTPase activator activityISOJ:164563
Molecular FunctionGO:0003924GTPase activityISOJ:164563
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0042802identical protein bindingIPIJ:196230
Molecular FunctionGO:0042802identical protein bindingIPIJ:196255
Molecular FunctionGO:0044325ion channel bindingISOJ:164563
Molecular FunctionGO:0016301kinase activityIEAJ:60000
Molecular FunctionGO:0004708MAP kinase kinase activityISOJ:164563
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0005515protein bindingIPIJ:169453
Molecular FunctionGO:0005515protein bindingIPIJ:183203
Molecular FunctionGO:0005515protein bindingIPIJ:183238
Molecular FunctionGO:0005515protein bindingIPIJ:183409
Molecular FunctionGO:0005515protein bindingIPIJ:186257
Molecular FunctionGO:0005515protein bindingIPIJ:196255
Molecular FunctionGO:0042803protein homodimerization activityISOJ:164563
Molecular FunctionGO:0004672protein kinase activityISOJ:164563
Molecular FunctionGO:0004674protein serine/threonine kinase activityISOJ:73065
Molecular FunctionGO:0017048Rho GTPase bindingISOJ:164563
Molecular FunctionGO:0017048Rho GTPase bindingIPIJ:183203
Molecular FunctionGO:0016740transferase activityIEAJ:60000
Molecular FunctionGO:0016772transferase activity, transferring phosphorus-containing groupsIEAJ:72247
Molecular FunctionGO:0015631tubulin bindingISOJ:164563
Cellular ComponentGO:0030424axonISOJ:155856
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0032473cytoplasmic side of mitochondrial outer membraneISOJ:164563
Cellular ComponentGO:0030425dendriteISOJ:155856
Cellular ComponentGO:0032839dendrite cytoplasmISOJ:164563
Cellular ComponentGO:0005622intracellularIEAJ:72247
Cellular ComponentGO:0043231intracellular membrane-bounded organelleISOJ:155856
Cellular ComponentGO:0016020membraneISOJ:155856
Cellular ComponentGO:0045121membrane raftIDAJ:121772
Cellular ComponentGO:0005739mitochondrionISOJ:164563
Cellular ComponentGO:0043005neuron projectionISOJ:155856
Cellular ComponentGO:0043005neuron projectionISOJ:164563
Cellular ComponentGO:0043025neuronal cell bodyISOJ:164563
Cellular ComponentGO:0005886plasma membraneIDAJ:121772
Cellular ComponentGO:0045202synapseIDAJ:183238
Cellular ComponentGO:0008021synaptic vesicleIDAJ:121772
Cellular ComponentGO:0005802trans-Golgi networkIDAJ:121772
Biological ProcessGO:0000187activation of MAPK activityISOJ:164563
Biological ProcessGO:0000186activation of MAPKK activityISOJ:164563
Biological ProcessGO:0006914autophagyIEAJ:60000
Biological ProcessGO:0008340determination of adult lifespanISOJ:164563
Biological ProcessGO:0035640exploration behaviorISOJ:164563
Biological ProcessGO:0006184GTP catabolic processISOJ:164563
Biological ProcessGO:0048312intracellular distribution of mitochondriaISOJ:164563
Biological ProcessGO:0000165MAPK cascadeISOJ:164563
Biological ProcessGO:2000173negative regulation of branching morphogenesis of a nerveISOJ:164563
Biological ProcessGO:0061002negative regulation of dendritic spine morphogenesisISOJ:164563
Biological ProcessGO:0034260negative regulation of GTPase activityISOJ:183238
Biological ProcessGO:0007406negative regulation of neuroblast proliferationISOJ:164563
Biological ProcessGO:0014043negative regulation of neuron maturationISOJ:164563
Biological ProcessGO:0007528neuromuscular junction developmentISOJ:164563
Biological ProcessGO:0070997neuron deathISOJ:164563
Biological ProcessGO:0021772olfactory bulb developmentISOJ:164563
Biological ProcessGO:0018105peptidyl-serine phosphorylationISOJ:164563
Biological ProcessGO:0018107peptidyl-threonine phosphorylationISOJ:164563
Biological ProcessGO:0016310phosphorylationIEAJ:60000
Biological ProcessGO:0010508positive regulation of autophagyIMPJ:160542
Biological ProcessGO:0010508positive regulation of autophagyISOJ:164563
Biological ProcessGO:0010942positive regulation of cell deathISOJ:164563
Biological ProcessGO:0060161positive regulation of dopamine receptor signaling pathwayISOJ:164563
Biological ProcessGO:0043547positive regulation of GTPase activityISOJ:164563
Biological ProcessGO:0043068positive regulation of programmed cell deathISOJ:164563
Biological ProcessGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processIMPJ:160542
Biological ProcessGO:0001934positive regulation of protein phosphorylationISOJ:164563
Biological ProcessGO:0031398positive regulation of protein ubiquitinationISOJ:164563
Biological ProcessGO:0046777protein autophosphorylationISAJ:113152
Biological ProcessGO:0046777protein autophosphorylationISOJ:164563
Biological ProcessGO:0006468protein phosphorylationISAJ:113152
Biological ProcessGO:0035564regulation of kidney sizeIMPJ:160542
Biological ProcessGO:0040012regulation of locomotionISOJ:164563
Biological ProcessGO:0042391regulation of membrane potentialISOJ:164563
Biological ProcessGO:0006979response to oxidative stressISOJ:164563
Biological ProcessGO:0007264small GTPase mediated signal transductionIEAJ:72247
Biological ProcessGO:0022028tangential migration from the subventricular zone to the olfactory bulbISOJ:164563

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory