About   Help   FAQ
GO Annotations Graph
 Symbol
Name
ID
P2rx7
purinergic receptor P2X, ligand-gated ion channel, 7
MGI:1339957

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Wed Jul 23 12:17:05 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005524ATP bindingIMPJ:84145
Molecular FunctionGO:0015267channel activityISOJ:137037
Molecular FunctionGO:0015267channel activityIMPJ:137037
Molecular FunctionGO:0004931extracellular ATP-gated cation channel activityIMPJ:84145
Molecular FunctionGO:0004931extracellular ATP-gated cation channel activityIMPJ:96213
Molecular FunctionGO:0004931extracellular ATP-gated cation channel activityISOJ:164563
Molecular FunctionGO:0005216ion channel activityIEAJ:72247
Molecular FunctionGO:0001530lipopolysaccharide bindingIDAJ:70817
Molecular FunctionGO:0005515protein bindingIPIJ:92523
Molecular FunctionGO:0001614purinergic nucleotide receptor activityIBAJ:161428
Molecular FunctionGO:0001614purinergic nucleotide receptor activityISOJ:164563
Molecular FunctionGO:0004872receptor activityIMPJ:84145
Cellular ComponentGO:0005911cell-cell junctionIDAJ:92523
Cellular ComponentGO:0009897external side of plasma membraneIDAJ:118682
Cellular ComponentGO:0016021integral component of membraneIEAJ:60000
Cellular ComponentGO:0005639integral component of nuclear inner membraneIBAJ:161428
Cellular ComponentGO:0005887integral component of plasma membraneISSJ:51040
Cellular ComponentGO:0005887integral component of plasma membraneIMPJ:84145
Cellular ComponentGO:0005622intracellularIMPJ:130842
Cellular ComponentGO:0016020membraneIDAJ:96213
Cellular ComponentGO:0016020membraneISOJ:164563
Cellular ComponentGO:0031594neuromuscular junctionIDAJ:96213
Cellular ComponentGO:0043025neuronal cell bodyIDAJ:99778
Cellular ComponentGO:0043025neuronal cell bodyIDAJ:103892
Cellular ComponentGO:0005886plasma membraneIDAJ:92523
Cellular ComponentGO:0045202synapseIDAJ:130842
Biological ProcessGO:0000187activation of MAPK activityIMPJ:118643
Biological ProcessGO:0032060bleb assemblyIMPJ:120291
Biological ProcessGO:0006816calcium ion transportIMPJ:79540
Biological ProcessGO:0006812cation transportIMPJ:84145
Biological ProcessGO:0006812cation transportISOJ:164563
Biological ProcessGO:0000902cell morphogenesisIMPJ:111397
Biological ProcessGO:0006884cell volume homeostasisIDAJ:130933
Biological ProcessGO:0031668cellular response to extracellular stimulusIMPJ:130842
Biological ProcessGO:0046513ceramide biosynthetic processIDAJ:110330
Biological ProcessGO:0032963collagen metabolic processIMPJ:136485
Biological ProcessGO:0019835cytolysisIMPJ:89513
Biological ProcessGO:0019835cytolysisIDAJ:113208
Biological ProcessGO:0019835cytolysisIDAJ:130933
Biological ProcessGO:0050830defense response to Gram-positive bacteriumIMPJ:118561
Biological ProcessGO:0097191extrinsic apoptotic signaling pathwayIMPJ:118682
Biological ProcessGO:0010467gene expressionIMPJ:137037
Biological ProcessGO:0048873homeostasis of number of cells within a tissueIMPJ:136485
Biological ProcessGO:0006954inflammatory responseIMPJ:111397
Biological ProcessGO:0006954inflammatory responseIMPJ:136485
Biological ProcessGO:0034220ion transmembrane transportIMPJ:96213
Biological ProcessGO:0006811ion transportIEAJ:60000
Biological ProcessGO:0006811ion transportIEAJ:72247
Biological ProcessGO:0006900membrane buddingIMPJ:99000
Biological ProcessGO:0051899membrane depolarizationISOJ:164563
Biological ProcessGO:0006509membrane protein ectodomain proteolysisIMPJ:118682
Biological ProcessGO:0007005mitochondrion organizationIDAJ:110330
Biological ProcessGO:0044254multicellular organismal protein catabolic processIDAJ:70817
Biological ProcessGO:0043132NAD transportIMPJ:125172
Biological ProcessGO:0045779negative regulation of bone resorptionIMPJ:84145
Biological ProcessGO:0043409negative regulation of MAPK cascadeIDAJ:70817
Biological ProcessGO:0001845phagolysosome assemblyIMPJ:118561
Biological ProcessGO:0006649phospholipid transfer to membraneIMPJ:79540
Biological ProcessGO:0045332phospholipid translocationIDAJ:130933
Biological ProcessGO:0007009plasma membrane organizationIDAJ:130933
Biological ProcessGO:0046931pore complex assemblyIMPJ:79540
Biological ProcessGO:0046931pore complex assemblyIMPJ:100823
Biological ProcessGO:0046931pore complex assemblyIMPJ:105908
Biological ProcessGO:0046931pore complex assemblyISOJ:164563
Biological ProcessGO:0043065positive regulation of apoptotic processIMPJ:110330
Biological ProcessGO:0043065positive regulation of apoptotic processIMPJ:136485
Biological ProcessGO:0030501positive regulation of bone mineralizationIMPJ:84145
Biological ProcessGO:0030501positive regulation of bone mineralizationIMPJ:137037
Biological ProcessGO:0010524positive regulation of calcium ion transport into cytosolISOJ:164563
Biological ProcessGO:0043085positive regulation of catalytic activityIMPJ:89513
Biological ProcessGO:0050715positive regulation of cytokine secretionIMPJ:136350
Biological ProcessGO:0014054positive regulation of gamma-aminobutyric acid secretionIMPJ:103703
Biological ProcessGO:0014049positive regulation of glutamate secretionIMPJ:103703
Biological ProcessGO:0014049positive regulation of glutamate secretionIMPJ:118643
Biological ProcessGO:0050717positive regulation of interleukin-1 alpha secretionIMPJ:136350
Biological ProcessGO:0032731positive regulation of interleukin-1 beta productionIMPJ:66835
Biological ProcessGO:0050718positive regulation of interleukin-1 beta secretionIMPJ:66835
Biological ProcessGO:0050718positive regulation of interleukin-1 beta secretionIMPJ:99000
Biological ProcessGO:0050718positive regulation of interleukin-1 beta secretionIMPJ:136350
Biological ProcessGO:0050718positive regulation of interleukin-1 beta secretionISOJ:164563
Biological ProcessGO:0032755positive regulation of interleukin-6 productionIMPJ:66835
Biological ProcessGO:0070230positive regulation of lymphocyte apoptotic processIMPJ:129413
Biological ProcessGO:0043410positive regulation of MAPK cascadeIMPJ:100823
Biological ProcessGO:0051901positive regulation of mitochondrial depolarizationIMPJ:102387
Biological ProcessGO:0045778positive regulation of ossificationIMPJ:105908
Biological ProcessGO:0045778positive regulation of ossificationIMPJ:137037
Biological ProcessGO:0032308positive regulation of prostaglandin secretionIMPJ:105908
Biological ProcessGO:0032308positive regulation of prostaglandin secretionIMPJ:105908
Biological ProcessGO:0001934positive regulation of protein phosphorylationIMPJ:100823
Biological ProcessGO:0001934positive regulation of protein phosphorylationIMPJ:121597
Biological ProcessGO:0050714positive regulation of protein secretionIDAJ:91940
Biological ProcessGO:0001916positive regulation of T cell mediated cytotoxicityIMPJ:89513
Biological ProcessGO:0012501programmed cell deathIMPJ:113208
Biological ProcessGO:0012501programmed cell deathIDAJ:130933
Biological ProcessGO:0051259protein oligomerizationIDAJ:96213
Biological ProcessGO:0006468protein phosphorylationIMPJ:118643
Biological ProcessGO:0016485protein processingIMPJ:66835
Biological ProcessGO:0035590purinergic nucleotide receptor signaling pathwayIBAJ:161428
Biological ProcessGO:0035590purinergic nucleotide receptor signaling pathwayISOJ:164563
Biological ProcessGO:0072593reactive oxygen species metabolic processIMPJ:121597
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolIMPJ:130842
Biological ProcessGO:0033198response to ATPIMPJ:66835
Biological ProcessGO:0033198response to ATPIMPJ:89513
Biological ProcessGO:0033198response to ATPIDAJ:91940
Biological ProcessGO:0033198response to ATPIDAJ:96213
Biological ProcessGO:0033198response to ATPIMPJ:99778
Biological ProcessGO:0033198response to ATPIMPJ:100823
Biological ProcessGO:0033198response to ATPIMPJ:102387
Biological ProcessGO:0033198response to ATPIMPJ:110330
Biological ProcessGO:0033198response to ATPIMPJ:111397
Biological ProcessGO:0033198response to ATPIMPJ:113208
Biological ProcessGO:0033198response to ATPIMPJ:118561
Biological ProcessGO:0033198response to ATPIMPJ:118682
Biological ProcessGO:0033198response to ATPIMPJ:120291
Biological ProcessGO:0033198response to ATPIMPJ:121597
Biological ProcessGO:0033198response to ATPIMPJ:130842
Biological ProcessGO:0033198response to ATPIMPJ:130933
Biological ProcessGO:0033198response to ATPIMPJ:136350
Biological ProcessGO:0033198response to ATPIMPJ:137037
Biological ProcessGO:0033198response to ATPISOJ:164563
Biological ProcessGO:0009617response to bacteriumIMPJ:97422
Biological ProcessGO:0051592response to calcium ionIDAJ:91940
Biological ProcessGO:0051592response to calcium ionIMPJ:99778
Biological ProcessGO:0051592response to calcium ionIMPJ:130842
Biological ProcessGO:0042493response to drugIMPJ:130842
Biological ProcessGO:0051602response to electrical stimulusIMPJ:103703
Biological ProcessGO:0034405response to fluid shear stressIMPJ:105908
Biological ProcessGO:0032496response to lipopolysaccharideIDAJ:91940
Biological ProcessGO:0032496response to lipopolysaccharideIMPJ:111397
Biological ProcessGO:0032496response to lipopolysaccharideIMPJ:121597
Biological ProcessGO:0009612response to mechanical stimulusIMPJ:105908
Biological ProcessGO:0014070response to organic cyclic compoundIDAJ:91940
Biological ProcessGO:0010033response to organic substanceIMPJ:113208
Biological ProcessGO:0010033response to organic substanceIMPJ:118682
Biological ProcessGO:0010033response to organic substanceIMPJ:129123
Biological ProcessGO:0010043response to zinc ionIMPJ:99778
Biological ProcessGO:0010043response to zinc ionIMPJ:130842
Biological ProcessGO:0019233sensory perception of painIMPJ:101945
Biological ProcessGO:0048705skeletal system morphogenesisIMPJ:137037
Biological ProcessGO:0016079synaptic vesicle exocytosisIMPJ:96213
Biological ProcessGO:0043029T cell homeostasisIMPJ:113208
Biological ProcessGO:0042098T cell proliferationIMPJ:118862
Biological ProcessGO:0006810transportIEAJ:60000

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory