GO Annotations Graph

Symbol
Name
ID

Cdkn2a
cyclin-dependent kinase inhibitor 2A
MGI:104738

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Tue May 21 18:05:30 2013.

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA	J:28319
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA	J:77997
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	ISO	J:164563
Molecular Function	GO:0051059	NF-kappaB binding	ISO	J:164563
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:94162
Molecular Function	GO:0005515	protein binding	IPI	J:143694
Molecular Function	GO:0005515	protein binding	IPI	J:189986
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0003700	sequence-specific DNA binding transcription factor activity	IDA	J:79357
Molecular Function	GO:0008134	transcription factor binding	ISO	J:164563
Molecular Function	GO:0055105	ubiquitin-protein ligase inhibitor activity	IDA	J:51904
Cellular Component	GO:0005737	cytoplasm	IDA	J:79357
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0001652	granular component	IDA	J:79357
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0016604	colocalizes_with nuclear body	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	IDA	J:72910
Cellular Component	GO:0005730	nucleolus	IDA	J:79357
Cellular Component	GO:0005730	nucleolus	IDA	J:94162
Cellular Component	GO:0005730	nucleolus	IDA	J:94174
Cellular Component	GO:0005730	nucleolus	IDA	J:99711
Cellular Component	GO:0005730	nucleolus	IDA	J:101353
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	IDA	J:79357
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0043234	protein complex	ISO	J:164563
Cellular Component	GO:0035985	senescence-associated heterochromatin focus	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0007568	aging	IMP	J:72780
Biological Process	GO:0006309	apoptotic DNA fragmentation	ISO	J:164563
Biological Process	GO:0008637	apoptotic mitochondrial changes	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0007569	cell aging	IDA	J:74741
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0007050	cell cycle arrest	IDA	J:28319
Biological Process	GO:0007050	cell cycle arrest	ISO	J:164563
Biological Process	GO:0007050	cell cycle arrest	ISO	J:164563
Biological Process	GO:0000075	cell cycle checkpoint	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0008544	epidermis development	IMP	J:72780
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0006917	induction of apoptosis	ISO	J:164563
Biological Process	GO:0006917	induction of apoptosis	ISO	J:164563
Biological Process	GO:0030889	negative regulation of B cell proliferation	IMP	J:105559
Biological Process	GO:0045786	negative regulation of cell cycle	IDA	J:94174
Biological Process	GO:0030308	negative regulation of cell growth	IMP	J:79357
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell proliferation	ISO	J:164563
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	J:77997
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0033088	negative regulation of immature T cell proliferation in thymus	IMP	J:105559
Biological Process	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	IMP	J:91428
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0042326	negative regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of transcription, DNA-dependent	ISO	J:164563
Biological Process	GO:0051444	negative regulation of ubiquitin-protein ligase activity	IDA	J:51904
Biological Process	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution	IMP	J:91428
Biological Process	GO:0071158	positive regulation of cell cycle arrest	ISO	J:164563
Biological Process	GO:2000774	positive regulation of cellular senescence	ISO	J:164563
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	IC	J:51904
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:2000111	positive regulation of macrophage apoptotic process	IGI	J:170042
Biological Process	GO:0033235	positive regulation of protein sumoylation	ISO	J:164563
Biological Process	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	IMP	J:144234
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	IGI	J:170042
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	ISO	J:164563
Biological Process	GO:0045893	positive regulation of transcription, DNA-dependent	IMP	J:144234
Biological Process	GO:0045893	positive regulation of transcription, DNA-dependent	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0070534	protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	J:28319
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IMP	J:70387
Biological Process	GO:0046822	regulation of nucleocytoplasmic transport	IGI	J:94174
Biological Process	GO:0046825	regulation of protein export from nucleus	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	IMP	J:79357
Biological Process	GO:0006355	regulation of transcription, DNA-dependent	IDA	J:79357
Biological Process	GO:0090399	replicative senescence	ISO	J:164563
Biological Process	GO:0042493	response to drug	ISO	J:155856
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0010243	response to organic nitrogen	ISO	J:155856
Biological Process	GO:0006364	rRNA processing	IEA	J:60000
Biological Process	GO:0009303	rRNA transcription	IGI	J:142821
Biological Process	GO:0035986	senescence-associated heterochromatin focus assembly	ISO	J:164563
Biological Process	GO:0048103	somatic stem cell division	IMP	J:105559
Biological Process	GO:0035019	somatic stem cell maintenance	IGI	J:144068
Biological Process	GO:0006351	transcription, DNA-dependent	IEA	J:60000

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IAS Inferred from ancestral seqeuence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IKR Inferred from key residues

IMP Inferred from mutant phenotype

IMR Inferred from missing residues

IPI Inferred from physical interaction

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Obsolete Evidence Code: Not Recorded

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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