About   Help   FAQ
Phenotype Images associated with this Gene
Symbol
Name
ID
Tgfb1
transforming growth factor, beta 1
MGI:98725


10 phenotype image(s) for Tgfb1 alleles
Showing image(s) 1 to 10

Click on thumbnail to view full size image with links to phenotype annotations.
Click on allele symbol for full phenotype details.

Caption: A, improved survival of Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul mice. B, reduced body weight of male mutants. C, photos of B6129 female mice showing reduced size and kyphosis. D, faxitron images and photos of a pair of male mice at 27 weeks illustrating the hunchback posture. E, teeth of mutant mice show signs of undermineralization and chipping. F, decreased mineral density and dental attrition (details)
Represented Alleles:
Tgfb1tm1(Tgfb3)Kul, transforming growth factor, beta 1; targeted mutation 1, Ashok B Kulkarni
Copyright: This image is from Hall BE, J Biol Chem 2013 Nov 1;288(44):32074-92 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:204892
Caption: A, histology of the femoral condyle shows defects in secondary ossification in a 40-week old Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul mouse. B, representative microcomputed tomography colored images from younger mutant and wild-type mice (14 weeks old) confirm the defects seen in the histology. C, osteocalcin staining for osteoblasts (details)
Represented Alleles:
Tgfb1tm1(Tgfb3)Kul, transforming growth factor, beta 1; targeted mutation 1, Ashok B Kulkarni
Copyright: This image is from Hall BE, J Biol Chem 2013 Nov 1;288(44):32074-92 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:204892
Caption: B6129 Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul mice remain small and thin although the control littermate mice show weight gain on a high fat dough diet (details)
Represented Alleles:
Tgfb1tm1(Tgfb3)Kul, transforming growth factor, beta 1; targeted mutation 1, Ashok B Kulkarni
Copyright: This image is from Hall BE, J Biol Chem 2013 Nov 1;288(44):32074-92 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:204892
Caption: C, adipose tissue underlying the skin dermis is reduced in an aged Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul mouse. D, Mutant mice do not develop steatosis ilike wild-type mice. E, adipocyte size is reduced in the mutant mice (details)
Represented Alleles:
Tgfb1tm1(Tgfb3)Kul, transforming growth factor, beta 1; targeted mutation 1, Ashok B Kulkarni
Copyright: This image is from Hall BE, J Biol Chem 2013 Nov 1;288(44):32074-92 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:204892
Caption: Tgfb1tm1Jmu/Tgfb1tm1Jmu mice develop fatal multiorgan inflammation (details)
Represented Alleles:
Tgfb1tm1Jmu, transforming growth factor, beta 1; targeted mutation 1, John Munger
Copyright: This image is from Yang Z, J Cell Biol 2007 Mar 12;176(6):787-93, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:120085
Caption: Abnormal vascular development in Tgfb1tm1Jmu/Tgfb1tm1Jmu mice and fewer Langerhans cells in Tgfb1tm1Jmu/Tgfb1tm1Jmu and Itgb6tm1Des/Itgb6tm1Des mice (details)
Represented Alleles:
Itgb6tm1Des, integrin beta 6; targeted mutation 1, Dean Sheppard
Tgfb1tm1Jmu, transforming growth factor, beta 1; targeted mutation 1, John Munger
Copyright: This image is from Yang Z, J Cell Biol 2007 Mar 12;176(6):787-93, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:120085
Caption: Gross tooth abnormalities in Tg(Dspp-TGFB1)3Kul/? mice (details)
Represented Alleles:
Tg(Dspp-TGFB1)3Kul, transgene insertion 3, Ashok B Kulkarni
Copyright: This image is from Thyagarajan T, J Biol Chem 2001 Apr 6;276(14):11016-20 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:118918
Caption: Tg(Dspp-TGFB1)3Kul/? molars exhibit an irregular odontoblast layer and dentinal tubules with cellular inclusions (details)
Represented Alleles:
Tg(Dspp-TGFB1)3Kul, transgene insertion 3, Ashok B Kulkarni
Copyright: This image is from Thyagarajan T, J Biol Chem 2001 Apr 6;276(14):11016-20 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:118918
Caption: Tg(Dspp-TGFB1)3Kul/? teeth exhibit abnormal and irregular dentin (details)
Represented Alleles:
Tg(Dspp-TGFB1)3Kul, transgene insertion 3, Ashok B Kulkarni
Copyright: This image is from Thyagarajan T, J Biol Chem 2001 Apr 6;276(14):11016-20 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:118918
Caption: Histopathological analysis on lung and heart tissues of Tgfb1tm1N/Tgfb1tm1N mice (details)
Represented Alleles:
Tgfb1tm1N, transforming growth factor, beta 1; targeted mutation 1, National Institutes of Health
Copyright: This image is from Kulkarni AB, Proc Natl Acad Sci U S A 1993 Jan 15;90(2):770-4. Copyright 1993 National Academy of Sciences, U.S.A. J:50848

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory