Phenotype Images associated with this Gene

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Phenotype Images associated with this Gene

Symbol
Name
ID

Grn
granulin
MGI:95832

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Click on allele symbol for full phenotype details.

	Caption: Microgliosis, thalamic neuronal TDP-43+ cytoplasmic inclusions, reduced synaptic density, lipofuscinosis, and skin lesions due to excessive grooming in Grn^tm2.1Far/Grn^tm2.1Far mice (details) Represented Alleles: Grn^tm2.1Far, granulin; targeted mutation 2.1, Bob Farese Copyright: This image is from Nguyen AD, Proc Natl Acad Sci U S A 2018 Mar 20;115(12):E2849-E2858. Copyright 2018 National Academy of Sciences, U.S.A. J:259651
	Caption: Increased total and phosphorylated TDP-43 in the cytoplasm of thalamic neurons in Grn^tm2.1Far/Grn^tm2.1Far and Grn^tm1.1Far/Grn^tm1.1Far mice (details) Represented Alleles: Grn^tm1.1Far, granulin; targeted mutation 1.1, Bob Farese Grn^tm2.1Far, granulin; targeted mutation 2.1, Bob Farese Copyright: This image is from Nguyen AD, Proc Natl Acad Sci U S A 2018 Mar 20;115(12):E2849-E2858. Copyright 2018 National Academy of Sciences, U.S.A. J:259651
	Caption: Exaggerated tissue inflammation in Grn^tm1.1Aidi/Grn^tm1.1Aidi mice after infection with L. monocytogenes (details) Represented Alleles: Grn^tm1.1Aidi, granulin; targeted mutation 1.1, Aihao Ding Copyright: This image is from Yin F, J Exp Med 2010 Jan 18;207(1):117-28, S1-4, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:156824
	Caption: Augmented activation of microglia and astrocytes in the brain of aged Grn^tm1.1Aidi/Grn^tm1.1Aidi mice (details) Represented Alleles: Grn^tm1.1Aidi, granulin; targeted mutation 1.1, Aihao Ding Copyright: This image is from Yin F, J Exp Med 2010 Jan 18;207(1):117-28, S1-4, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:156824
	Caption: Augmented age-dependent activation of microglia and astrocytes in the brains of Grn^tm1.1Aidi/Grn^tm1.1Aidi mice (details) Represented Alleles: Grn^tm1.1Aidi, granulin; targeted mutation 1.1, Aihao Ding Copyright: This image is from Yin F, J Exp Med 2010 Jan 18;207(1):117-28, S1-4, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:156824

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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