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Phenotype Images associated with this Gene
Symbol
Name
ID
Grn
granulin
MGI:95832


5 phenotype image(s) for Grn alleles
Showing image(s) 1 to 5

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Click on allele symbol for full phenotype details.

Caption: Microgliosis, thalamic neuronal TDP-43+ cytoplasmic inclusions, reduced synaptic density, lipofuscinosis, and skin lesions due to excessive grooming in Grntm2.1Far/Grntm2.1Far mice (details)
Represented Alleles:
Grntm2.1Far, granulin; targeted mutation 2.1, Bob Farese
Copyright: This image is from Nguyen AD, Proc Natl Acad Sci U S A 2018 Mar 20;115(12):E2849-E2858. Copyright 2018 National Academy of Sciences, U.S.A. J:259651
Caption: Increased total and phosphorylated TDP-43 in the cytoplasm of thalamic neurons in Grntm2.1Far/Grntm2.1Far and Grntm1.1Far/Grntm1.1Far mice (details)
Represented Alleles:
Grntm1.1Far, granulin; targeted mutation 1.1, Bob Farese
Grntm2.1Far, granulin; targeted mutation 2.1, Bob Farese
Copyright: This image is from Nguyen AD, Proc Natl Acad Sci U S A 2018 Mar 20;115(12):E2849-E2858. Copyright 2018 National Academy of Sciences, U.S.A. J:259651
Caption: Exaggerated tissue inflammation in Grntm1.1Aidi/Grntm1.1Aidi mice after infection with L. monocytogenes (details)
Represented Alleles:
Grntm1.1Aidi, granulin; targeted mutation 1.1, Aihao Ding
Copyright: This image is from Yin F, J Exp Med 2010 Jan 18;207(1):117-28, S1-4, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:156824
Caption: Augmented activation of microglia and astrocytes in the brain of aged Grntm1.1Aidi/Grntm1.1Aidi mice (details)
Represented Alleles:
Grntm1.1Aidi, granulin; targeted mutation 1.1, Aihao Ding
Copyright: This image is from Yin F, J Exp Med 2010 Jan 18;207(1):117-28, S1-4, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:156824
Caption: Augmented age-dependent activation of microglia and astrocytes in the brains of Grntm1.1Aidi/Grntm1.1Aidi mice (details)
Represented Alleles:
Grntm1.1Aidi, granulin; targeted mutation 1.1, Aihao Ding
Copyright: This image is from Yin F, J Exp Med 2010 Jan 18;207(1):117-28, S1-4, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:156824

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory