Phenotype Images associated with this Gene

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Phenotype Images associated with this Gene

Symbol
Name
ID

Smad4
SMAD family member 4
MGI:894293

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Click on allele symbol for full phenotype details.

	Caption: Pancreatic fibrosis and acinar-to-ductal metaplasia in Tg(MtTGFA)Lmb/0 (MT-TGFalpha) and Smad4^tm1.1Gsu/Smad4^tm1.1Gsu Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Tg(MtTGFA)Lmb/0 (STP) mice (details) Represented Alleles: Ptf1a^{tm1.1(cre)Cvw}, pancreas specific transcription factor, 1a; targeted mutation 1.1, Christopher VE Wright Smad4^tm1.1Gsu, SMAD family member 4; targeted mutation 1.1, Gloria H Su Tg(MtTGFA)Lmb, transgene insertion, Glenn Merlino Copyright: This image is from Garcia-Carracedo D, PLoS One 2015;10(3):e0120851, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:229184
	Caption: Increased number of PanIN lesions in the Smad4^tm1.1Gsu/Smad4^tm1.1Gsu Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Tg(MtTGFA)Lmb/0 (STP) mice compared to Tg(MtTGFA)Lmb/0 (MT-TGFalpha) mice (details) Represented Alleles: Ptf1a^{tm1.1(cre)Cvw}, pancreas specific transcription factor, 1a; targeted mutation 1.1, Christopher VE Wright Smad4^tm1.1Gsu, SMAD family member 4; targeted mutation 1.1, Gloria H Su Tg(MtTGFA)Lmb, transgene insertion, Glenn Merlino Copyright: This image is from Garcia-Carracedo D, PLoS One 2015;10(3):e0120851, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:229184
	Caption: Enhanced pancreatic epithelial expasnion in Smad4^tm1.1Gsu/Smad4^tm1.1Gsu Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Tg(MtTGFA)Lmb/0 mice compared to Tg(MtTGFA)Lmb/0 mice (details) Represented Alleles: Ptf1a^{tm1.1(cre)Cvw}, pancreas specific transcription factor, 1a; targeted mutation 1.1, Christopher VE Wright Smad4^tm1.1Gsu, SMAD family member 4; targeted mutation 1.1, Gloria H Su Tg(MtTGFA)Lmb, transgene insertion, Glenn Merlino Copyright: This image is from Garcia-Carracedo D, PLoS One 2015;10(3):e0120851, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:229184
	Caption: Aggravated pancreatic fibrosis in Smad4^tm1.1Gsu/Smad4^tm1.1Gsu Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Tg(MtTGFA)Lmb/0 mice compared to Tg(MtTGFA)Lmb/0 mice (details) Represented Alleles: Ptf1a^{tm1.1(cre)Cvw}, pancreas specific transcription factor, 1a; targeted mutation 1.1, Christopher VE Wright Smad4^tm1.1Gsu, SMAD family member 4; targeted mutation 1.1, Gloria H Su Tg(MtTGFA)Lmb, transgene insertion, Glenn Merlino Copyright: This image is from Garcia-Carracedo D, PLoS One 2015;10(3):e0120851, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:229184
	Caption: Elevated Mucin-6 expression indicates pancreatitis in Smad4^tm1.1Gsu/Smad4^tm1.1Gsu Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Tg(MtTGFA)Lmb/0 (STP) mice (details) Represented Alleles: Ptf1a^{tm1.1(cre)Cvw}, pancreas specific transcription factor, 1a; targeted mutation 1.1, Christopher VE Wright Smad4^tm1.1Gsu, SMAD family member 4; targeted mutation 1.1, Gloria H Su Tg(MtTGFA)Lmb, transgene insertion, Glenn Merlino Copyright: This image is from Garcia-Carracedo D, PLoS One 2015;10(3):e0120851, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:229184
	Caption: Phenotypic analysis of the compound in cis Apc^tm2Rfo/Apc⁺ Smad4^E6sad/Smad4⁺ mouse model (details) Represented Alleles: Apc^tm2Rfo, APC, WNT signaling pathway regulator; targeted mutation 2, Riccardo Fodde Smad4^E6sad, SMAD family member 4; Exon 6 splice acceptor deletion Copyright: This image is from Gaspar C, PLoS Genet 2009 Jul;5(7):e1000547, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151494
	Caption: Stomach and stomach sections of 11 month old wild type and Smad4^m4Mag/+ mice. (details) Represented Alleles: Smad4^m4Mag, SMAD family member 4; mutation 4, Terry Magnuson Copyright: This image is from Chen Y, Mamm Genome 2006 Mar;17(3):211-9 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:106440
	Caption: Morphological and molecular analyses of Smad4^tm1Cxd/Smad4^tm1Cxd embryos (details) Represented Alleles: Smad4^tm1Cxd, SMAD family member 4; targeted mutation 1, Chu-Xia Deng Copyright: This image is from Yang X, Proc Natl Acad Sci U S A 1998 Mar 31;95(7):3667-72. Copyright 1998 National Academy of Sciences, U.S.A. J:46852

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