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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ireb2tm1.1Eal
Name: iron responsive element binding protein 2; targeted mutation 1.1, Elizabeth A Leibold
MGI ID: MGI:5702744
Synonyms: Irp2-
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Iron accumulates in specific brain regions of Ireb2tm1.1Eal/Ireb2tm1.1Eal miceIreb2tm1.1Eal/Ireb2tm1.1EalB6J.129-Ireb2tm1.1Eal
Iron accumulates in axons and oliogodendrocyte cell bodies of Ireb2tm1.1Eal/Ireb2tm1.1Eal miceIreb2tm1.1Eal/Ireb2tm1.1EalB6J.129-Ireb2tm1.1Eal
Iron is reduced in Purkinje neurons and in CA1 pyramidal neurons of Ireb2tm1.1Eal/Ireb2tm1.1Eal miceIreb2tm1.1Eal/Ireb2tm1.1EalB6J.129-Ireb2tm1.1Eal
Ferritin expression is increased in Ireb2tm1.1Eal/Ireb2tm1.1Eal neuronsIreb2tm1.1Eal/Ireb2tm1.1EalB6J.129-Ireb2tm1.1Eal
Presence of Protoporphyrin IX-containing granules in the common bile duct of Ireb2tm1.1Eal/Ireb2tm1.1Eal miceIreb2tm1.1Eal/Ireb2tm1.1EalB6J.129-Ireb2tm1.1Eal
Iron accumulation in hippocampus and cerebellum of aged Ireb2tm1.1Eal/Ireb2tm1.1Eal miceIreb2tm1.1Eal/Ireb2tm1.1EalB6J.129-Ireb2tm1.1Eal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory