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Phenotype Images associated with this Allele
Nomenclature
Symbol: Myh10b2b2437Clo
Name: myosin, heavy polypeptide 10, non-muscle; Bench to Bassinet Program (B2B/CVDC), mutation 2437 Cecilia Lo
MGI ID: MGI:5552947
Synonyms: Moe
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2437-005-3 (E16.5) exhibits parallel outflow tracts and is diagnosed with DORV and ventricular non-compaction by EFIC imagingMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
EFIC SummaryMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Serial 2D EFIC image stack in the coronal plane of 2437-005-3 (E16.5) reveals DORV with a non-committed VSD, and venticular non-compaction
Click thumbnail to play movie.
Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Color flow spectral Doppler imaging of mutant 2437-005-003 (E16.5) in the sagittal view shows two great arteries originating from RV primarily, suggesting DORV
Click thumbnail to play movie.
Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-3 (E16.5) presents with exencephaly and micrognathiaMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-3 (E16.5) shows exencephaly and cleft lipMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-006-1 (E16.5) presents with exencephalyMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-006-1 (E16.5) shows exencephaly and facial clefting or cleft lipMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-006-1 (E16.5) has interrupted aortic arch and non-compaction of the ventricles which is confimed by EFIC imagingMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-006-1 (E16.5) exhibits an interrupted aortic arch and abnormal positioning of the outflows that is diagnosed as overriding aorta by EFIC imagingMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
EFIC SummaryMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Serial 2D EFIC image stack in the coronal plane of 2437-006-1 (E16.5) reveals an overriding aorta, AVSD, interrupted aortic arch (type B), and ventricular non-compaction
Click thumbnail to play movie.
Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Color flow spectral Doppler imaging of mutant 2437-006-1 (E16.5) in the sagittal view shows the two great arteries originating from RV predominantly, suggesting overriding aorta
Click thumbnail to play movie.
Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Color flow spectral Doppler imaging of mutant 2437-006-1 (E16.5) in the transverse view shows shunting between LV and RV, suggesting atrioventricular septal defect (AVSD)
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Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-2 (E16.5) exhibited exencehpaly and was found deadMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-2 (E16.5) presents with cleft lip and micrognathiaMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-2 (E16.5) shows abnormal patterning on ventricles which indicates ventricular non-compaction and is confirmed by EFIC imagingMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-2 (E16.5) shows malalignment of the great arteries, which EFIC imaging shows is DORVMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
EFIC SummaryMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Serial 2D EFIC image stack in the coronal plane of 2437-005-2 (E16.5) reveals DORV, AVSD, and ventricular non-compaction
Click thumbnail to play movie.
Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory