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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b2059Clo
Name: Mutant line 2059; Bench to Bassinet Program (B2B/CVDC), mutation 2059 Cecilia Lo
MGI ID: MGI:5491238
Synonyms: Morse
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2059-013-NA exhibits heterotaxy with left lung isomerism (1R/1L), midline IVC, and DORV, which are all confirmed by EFIC imagingb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
EFIC Summaryb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Serial 2D EFIC image stack in the coronal plane of 2059-013-NA shows DORV {A(I),D,D}, AVSD, mVSD, left lung isomerism, and left-sided IVC
Click thumbnail to play movie.
b2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Serial micro-MRI image stack in the coronal plane of 2059-013-NA reveals heterotaxy, DORV, AVSD, mid to left-sided IVC {A(I),D,D}, left lung isomerism, and malpositioning of the stomach
Click thumbnail to play movie.
b2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-013-NA exhibits a malaligned sternal vertebraeb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-013-NA shows a stomach and pancreas that are midline and malpositionedb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-013-NA presents with a hypoplastic spleenb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-013-NA presents with cystic kidneysb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-013-NA has cystic kidneys (left kidney shown)b2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-007-1 (E14.5) exhibits heterotaxy with levocardia and dextrogastriab2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-007-1 (E14.5) exhibits anterior aorta which is confirmed as transposition of the great arteries (TGA) by EFIC imagingb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
EFIC Summaryb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Serial 2D EFIC image stack in the coronal plane of 2059-007-1 (E14.5) shows D-TGA {A,D,D}, AVSD, hypoplastic transverse aorta, and left atrial isomerism
Click thumbnail to play movie.
b2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-007-2 (E14.5) exhibits anterior aorta which is confirmed as transposition of the great arteries (TGA) by EFIC imagingb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
EFIC Summaryb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Serial 2D EFIC image stack in the coronal plane of 2059-007-2 (E14.5) shows D-TGA {S,D,D}, AVSD, incomplete vascular ring, thickened valves, and biventricular hypertrophy
Click thumbnail to play movie.
b2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Color flow spectral Doppler imaging of mutant 2059-007-2 (E14.5) in the front view shows the roots of two great arteries. Aorta originates form RV and PA originates from LV, suggesting TGAb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Color flow spectral Doppler imaging of mutant 2059-007-2 (E14.5) in the sagittal view shows aorta originating form RV and PA originating from LV, suggesting TGAb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-013-NB exhibits a malaligned sternal vertebraeb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
b2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-013-NB presents with cystic kidneysb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
EFIC Summaryb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Serial 2D EFIC image stack in the coronal plane of 2059-013-NB shows AVSD {A,D,D}, dual IVC, and left lung isomerism
Click thumbnail to play movie.
b2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Serial micro-MRI image stack in the coronal plane of 2059-013-NB reveals heterotaxy, AVSD, dual IVC connected to common atrium {A,D,D}, and left lung isomerism
Click thumbnail to play movie.
b2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-013-NB has cystic kidneys (right kidney shown)b2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-005-LA exhibits situs inversus totalis with dextrocardia and dextrogastriab2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-005-LA has slow, dyskinetic, and immotile ciliab2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Left kidney of mutant 2059-005-LA is hydronephroticb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-014-NA shows parallel outflow tracts which is diagnosed as overriding aorta by EFIC imagingb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
EFIC Summaryb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Serial 2D EFIC image stack in the coronal plane of 2059-014-NA shows overriding aorta {A,D,D}, AVSD, and common atrium
Click thumbnail to play movie.
b2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Mutant 2059-007-3 (E14.5) shows parallel outflow tracts which is diagnosed as DORV by EFIC imagingb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
EFIC Summaryb2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo
Serial 2D image stack of 2059-007-3 (E14.5) in the coronal plane reveals DORV and AVSD {A,D,D}
Click thumbnail to play movie.
b2b2059Clo/b2b2059CloC57BL/6J-b2b2059Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory