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Phenotype Images associated with this Allele
Nomenclature
Symbol: Plxnd1b2b1863Clo
Name: plexin D1; Bench to Bassinet Program (B2B/CVDC), mutation 1863 Cecilia Lo
MGI ID: MGI:5476170
Synonyms: Snowman
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1863-002-4 (E16.5) has a hypoplastic transverse arch and malaligned great arteriesPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Mutant 1863-002-4 (E16.5) shows hypoplastic arch with malaligned great arteriesPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Mutant 1863-002-4 (E16.5) has hypoplastic thymusPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
EFIC SummaryPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Serial 2D EFIC image stack in the coronal plane of mutant 1863-002-4 (E16.5) reveals DORV, subaortic VSD, and hypoplastic transverse aortic arch
Click thumbnail to play movie.		Plxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Mutant 1863-004-1 (E17.5) shows PTA and a right aortic archPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Mutant 1863-004-1 (E17.5) has a misshapened and mislocalized thymusPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Mutant 1863-004-1 (E17.5) shows a left duplex kidneyPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
EFIC SummaryPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Serial 2D EFIC image stack of 1863-004-1 (E17.5) in the coronal plane reveals Truncus Arterosus (Van Praagh A2) {A,D,D}, AVSD, right Aortic Arch, double IVS, myocardial non-compaction
Click thumbnail to play movie.		Plxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Mutant 1863-004-2 (E17.5) exhibits PTA with a right aortic archPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Mutant 1863-004-2 (E17.5) has a hypoplastic and misshapened thymusPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Mutant 1863-004-2 (E17.5) shows left kidney agenesisPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Mutant 1863-004-2(E17.5) exhibits a cleft palate which is consistent with DiGeorge syndromePlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
EFIC SummaryPlxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Serial 2D EFIC image stack of 1863-004-2 (E17.5) in the coronal plane reveals Persistent Truncus Arterosus (Van Praagh A2), AVSD {A,D,D}, right aortic arch, dual IVC, myocardial non-compaction
Click thumbnail to play movie.		Plxnd1b2b1863Clo/Plxnd1b2b1863CloC57BL/6J-Plxnd1b2b1863Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory