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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dnah11b2b1775Clo
Name: dynein, axonemal, heavy chain 11; Bench to Bassinet Program (B2B/CVDC) mutation 1775, Cecilia Lo
MGI ID: MGI:5446158
Synonyms: Blindfold, Dnahc11c.6489+2T
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1775-005-LA displays dextrocardia, inverted lung lobe, malrotation of intestinesDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
EFIC SummaryDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Serial 2D EFIC image stack of 1775-005-LA in the coronal view reveals dextrocardia {A,L,L}, dual IVC, inverted hemiazygous venous connection
Click thumbnail to play movie.		Dnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-005-LA displays malaligned sternal vertebrateDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-005-LA displays inverted anterior-posterior positioning of the kidneys, with left kidney higher than right. Also note abnormal dilated vessel near right adrenal gland.Dnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1774-005-LA displays intestinal malrotation, abnormal color (pale) left liver lobeDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-005-LA shows dyskinetic airway cilia motility as well as hyperkinetic airway cilia motility
Click thumbnail to play movie.		Dnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-005-LA shows dyskinetic and hyperkinetic airway cilia
Click thumbnail to play movie.		Dnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-003-NA with dextrocardia and ambiguous lung lobation with possible diaphragmatic herniation of the liver on the right.Dnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Serial 2D micro-CT image stack of 1775-003-NA in the coronal plane reveals heterotaxy, dextrocardia {A,L,L} inverted hemiazygous venous connection, hepatic vein connects to left side atrium. Abnormal lung lobation indicative of left pulmonary isomerism (2 right lobes, and single left lobe), abnormal liver position, left sided stomach.
Click thumbnail to play movie.		Dnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-003-NA exhibits hypoplastic spleenDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-002-LA displays situs inversus totalisDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-002-LA exhibits dyskinetic airway cilia with patches of immotile cilia
Click thumbnail to play movie.		Dnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-018-6 (E14.5) is a situs mutant with dextrocardia and dextrogastriaDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-018-6 (E14.5) exhibits dextrocardia and DORV which is diagnosed by EFICDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
EFIC summaryDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Serial 2D EFIC image stack in the coronal plane of 1775-018-6 (E14.5) shows dextrocardia, DORV, and subaortic VSD
Click thumbnail to play movie.		Dnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-018-9 (E14.5) is a situs mutant with dextrocardia and dextrogastriaDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Mutant 1775-018-9 (E14.5) has dextrocardia and DORV diagnosed by EFICDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
EFIC summaryDnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
Serial 2D EFIC image stack in the coronal plane of 1775-018-9 (E14.5) shows dextrocardia, DOmRV, and subaortic VSD
Click thumbnail to play movie.		Dnah11b2b1775Clo/Dnah11b2b1775CloC57BL/6J-Dnah11b2b1775Clo
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory