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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b1432Clo
Name: Mutant line 1432; Bench to Bassinet Program (B2B/CVDC), mutation 1432 Cecilia Lo
MGI ID: MGI:5445346
Synonyms: Hermey
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1432-005-LA displays slightly narrow aorta and hypoplastic left ventricle.b2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
EFIC Summaryb2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
Serial 2D EFIC image stack in the coronal plane of 1432-005-LA reveals Hypoplastic LV, critical aortic stenosis, small mitral valve (HLHS), trabeculation within the ventricular septum, dilated aortic root, thickend and dysplastic aortic valve, and dilated RV with non-compaction.
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b2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
Serial 2D EFIC image stack in the transverse plane of 1432-005-LA reveals dysplastic aortic valves, small left ventricle/mitral valve/left atrium, and normal sized left coronary artery
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b2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
Serial 2D MRI image stack in the coronal plane of 1432-005-LA reveals small left atrium and hypoplastic left ventricle
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b2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
Color flow spectral Doppler imaging of mutant 1432-005-LA in the sagittal view shows much less blood flow through aortic valve, suggesting severe aortic stenosisb2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
Color flow spectral Doppler movie of mutant 1432-005-LA in the sagittal view shows much less blood flow through the aortic valve, suggesting severe aortic stenosis
Click thumbnail to play movie.
b2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
Color flow spectral Doppler movie of mutant 1432-005-LA in the sagittal view shows alignment of two great arteries is normal, but there is reversal of aortic blood flow indicating severe aortic stenosis
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b2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
Color flow spectral Doppler imaging of mutant 1432-005-LA in the sagittal view shows aortic reverse blood flow, indicating severe aortic stenosisb2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
Spectral Doppler imaging of mutant 1432-005-LA in the sagittal view shows very high velocity at the level of the aortic valve, suggesting severe aortic stenosisb2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
2D imaging of mutant 1432-005-LA in the frontal view shows small LV chamber filled with a lot of tissue suggesting hypoplastic LVb2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
2D imaging of mutant 1432-005-LA in the sagittal view shows presence of the inlet to the left heartb2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo
Mutant 1432-005-LA presents with a short snoutb2b1432Clo/b2b1432CloC57BL/6J-b2b1432Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory