Phenotype Images associated with this Allele
|
Nomenclature
|
|
Symbol:
|
b2b1432Clo
|
|
Name:
|
Mutant line 1432;
Bench to Bassinet Program (B2B/CVDC), mutation 1432 Cecilia Lo
|
|
MGI ID:
|
MGI:5445346
|
|
Synonyms:
|
Hermey
|
|
Images for
Allele
|
Click images for details
 | Mutant 1432-005-LA displays slightly narrow aorta and hypoplastic left ventricle. | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | EFIC Summary | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | Serial 2D EFIC image stack in the coronal plane of 1432-005-LA reveals Hypoplastic LV, critical aortic stenosis, small mitral valve (HLHS), trabeculation within the ventricular septum, dilated aortic root, thickend and dysplastic aortic valve, and dilated RV with non-compaction.
Click thumbnail to play movie. | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | Serial 2D EFIC image stack in the transverse plane of 1432-005-LA reveals dysplastic aortic valves, small left ventricle/mitral valve/left atrium, and normal sized left coronary artery
Click thumbnail to play movie. | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | Serial 2D MRI image stack in the coronal plane of 1432-005-LA reveals small left atrium and hypoplastic left ventricle
Click thumbnail to play movie. | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | Color flow spectral Doppler imaging of mutant 1432-005-LA in the sagittal view shows much less blood flow through aortic valve, suggesting severe aortic stenosis | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | Color flow spectral Doppler movie of mutant 1432-005-LA in the sagittal view shows much less blood flow through the aortic valve, suggesting severe aortic stenosis
Click thumbnail to play movie. | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | Color flow spectral Doppler movie of mutant 1432-005-LA in the sagittal view shows alignment of two great arteries is normal, but there is reversal of aortic blood flow indicating severe aortic stenosis
Click thumbnail to play movie. | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | Color flow spectral Doppler imaging of mutant 1432-005-LA in the sagittal view shows aortic reverse blood flow, indicating severe aortic stenosis | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | Spectral Doppler imaging of mutant 1432-005-LA in the sagittal view shows very high velocity at the level of the aortic valve, suggesting severe aortic stenosis | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | 2D imaging of mutant 1432-005-LA in the frontal view shows small LV chamber filled with a lot of tissue suggesting hypoplastic LV | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | 2D imaging of mutant 1432-005-LA in the sagittal view shows presence of the inlet to the left heart | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
 | Mutant 1432-005-LA presents with a short snout | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo |
|
Analysis Tools