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Phenotype Images associated with this Allele
Nomenclature
Symbol: Lrp1b2b1554Clo
Name: low density lipoprotein receptor-related protein 1; Bench to Bassinet Program (B2B/CVDC), mutation 1554 Cecilia Lo
MGI ID: MGI:5437079
Synonyms: Marshmellow
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1554-004-1 (E14.5) exhibits gastroschisis with liver and gut outside the abdominal cavity (celoschisis)Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-004-1 (E14.5) exhibits narrowed pulmonary outflowLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-004-1 (E14.5) exhibits narrowed pulmonary outflowLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
EFIC SummaryLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Serial 2D EFIC image stack in the coronal plane of 1554-004-1 (E14.5) reveals AVSD (or closing interventricular foramen), small PA
Click thumbnail to play movie.
Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-004-1 (E14.5) exhibits gastroschsis with liver protruding outside of abdominal cavity (celoschisis)Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-4-2 exhibits narrowed pulmonary stenosisLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant 1554-004-2 (E14.5) shows pulmonary stenosisLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-004-1 (E14.5) exhibits body wall closure defect with liver protruding outside of abdominal cavity (celoschisis)Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-004-1 (E14.5) exhibits body wall closure defect with liver protruding outside of abdominal cavity (celoschisis)Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
EFIC SummaryLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Serial 2D EFIC image stack of mutant fetus 1554-004-2 (E14.5) shows DORV with pulmonary stenosis and AVSD
Click thumbnail to play movie.
Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-007-1 (E14.5) exhibits single outflow tract with abdominal organ projecting into thoracic cavity, indicating a diaphragmatic herniaLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-007-1 (E14.5) exhibits single outflow tract with abdominal organ projecting into thoracic cavity, indicating a diaphragmatic herniaLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-007-1 (E14.5) exhibits single outflow tract with abdominal organ protruding into chest cavity indicating diaphragmatic herniaLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant 1554-007-1 exhibits umbilical herniation indicative of an omphalocele type body wall closure defectLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-007-1 (E14.5) exhibits a single outflow tract, indicating persistent truncus arteriosus (PTA)Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
EFIC SummaryLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Serial 2D EFIC image stack in the coronal plane of 1554-007-1 (E16.5) reveals persistence truncus arteriosis (PTA/Type II) hypoplastic PA {S,D,D}
Click thumbnail to play movie.
Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Color flow spectral Doppler imaging of mutant 1554-007-1 (E16.5) in the frontal view shows a single outflow tract suggesting PTA with regurgitation and VSD
Click thumbnail to play movie.
Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Snapshot of color flwo spectral Doppler movie of mutant 1554-007-1 (E16.5) in the frontal view shows a single outflow tract suggesting PTA and VSDLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory