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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ltbp1b2b1000Clo
Name: latent transforming growth factor beta binding protein 1; Bench to Bassinet Program (B2B/CvDC) mutation 1000, Cecilia Lo
MGI ID: MGI:5316784
Synonyms: Millenium
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Persistent truncus arteriosus (PTA) found in mutant 1000-007-3 (E16.5)Ltbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
2D serial EFIC image stack in the coronal view of mutant 1000-007-3 (E16.5) reveals PTA (type II) and right aortic arch
Click thumbnail to play movie.
Ltbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
H&E staining of 1000-007-1 (E16.5) kidneys show glomerular cysts and some tubule dilations.Ltbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
Immunofluorescence of collecting duct (green) of mutant 1000-007-1 (E16.5) reveals normal cilia (red)Ltbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
Immunofluorescence of collecting duct/ureteric bud (green) of mutant 1000-007-1 (E16.5) reveals normal cilia (red)Ltbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
Cystic kidneys in mutant 1000-007-1 (E16.5) confirmed by histologyLtbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
Parallel outflow tracts indicates double outlet right ventricle (DORV) in mutant 1000-004-1 (E15.5) confirmed by EFIC imagingLtbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
EFIC summaryLtbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
2D serial EFIC image stack in the coronal view of mutant 1000-004-1 (E15.5) reveals DORV {SDD}, subaortic VSD, right aortic arch, and vascular ring.
Click thumbnail to play movie.
Ltbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
Abnormal vasculature in mutant 1000-007-3 (E16.5)Ltbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
EFIC SummaryLtbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
Color flow imaging of mutant 1000-007-1 (E16.5) in sagittal view showed common truncus regurgitation with VSDLtbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
Color flow imaging of mutant 1000-007-1 (E16.5) in sagittal view showed common truncus with regurgitation and VSD, which suggested PTA
Click thumbnail to play movie.
Ltbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
Color flow imaging of mutant 1000-007-1 (E16.5) in sagittal view showed single outflow tract forward flow and VSDLtbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo
H&E staining of 1000-007-1 (E16.5) kidneys show glomerular cysts and some tubule dilations.Ltbp1b2b1000Clo/Ltbp1b2b1000CloC57BL/6J-Ltbp1b2b1000Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory