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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dnah5b2b002Clo
Name: dynein, axonemal, heavy chain 5; Bench to Bassinet Program (B2B/CVDC), mutation 002 Cecilia Lo
MGI ID: MGI:5294340
Synonyms: Scar, Scaramanga
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 002-044-NG exhibits heterotaxy with dextrocardia and abnormal position of the great arteries which is diagnosed as DORV by EFIC imagingDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Mutant 002-044-NG exhibits situs inversus totalis with dextrocardia, inverted lung and liver lobation, and dextrogastriaDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
EFIC SummaryDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Serial 2D EFIC image stack in the coronal plane of 002-044-NG reveals dextrocardia, Taussig-Bing DORV, AVSD {A,L,L}
Click thumbnail to play movie.		Dnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Mutant 022-044-NG presents with a slightly malaligned sternal vertebraDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Mutant 002-006-LDM presents with heterotaxy, including dextrocardia, abnormal lung lobation pattern, malrotation of intestine, and symmetric liverDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Mutant 002-006-LDM exhibits malposition of stomach (middle) and pancreas, as well as malrotation of intestinal tractDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Serial 2D micro-CT image stack in the coronal plane of 002-006-LCM reveals situs inversus totalis, right duplicated kidney and hydronephrosis
Click thumbnail to play movie.		Dnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Mutant 002-006-LDM has a right duplicated kidney and dilated renal pelvisDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Right kidney of mutant 002-006-LDM has hydronephrosis and small cystsDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Kidney of mutant 002-006-LDM has dilated collecting ductsDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
002-006-LG exhibits a hypoplastic spleenDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Videomicroscopy of mutant 002-006-LG reveals immotile tracheal airway cilia
Click thumbnail to play movie.		Dnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Videomicroscopy of mutant 002-044-LB reveals immotile tracheal airway cilia
Click thumbnail to play movie.		Dnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Mutant 002-038-NA presents with an anterior aorta which is diagnosed as D-TGA by EFIC imagingDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Mutant 002-038-NA presents with heterotaxy including levocardia, dextrogastria, right lung and liver isomerismDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
EFIC SummaryDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Serial 2D EFIC image stack in the coronal plane of 002-038-NA reveals TGA, VSD, ASD (AVSD), hypoplastic transverse aorta, left sided IVC or hepatic vein, dilated azgous vein running down to the abdominal cavity {A,D,D}.
Click thumbnail to play movie.		Dnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Mutant 022-038-NA exhibits a malaligned sternumDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Mutant 002-050-LA exhibits situs inversus totalis with dextrocardia, inverted lung lobation, inverted liver lobation, and dextrogastriaDnah5b2b002Clo/Dnah5b2b002CloC57BL/6J-Dnah5b2b002Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory