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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ryr1tm1.1Dhm
Name: ryanodine receptor 1, skeletal muscle; targeted mutation 1.1, David H MacLennan
MGI ID: MGI:4418317
Synonyms: Ryr1I4895T, Ryr1IT
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Kyphosis, hindlimb paresis and myofiber abnormalities in Ryr1tm1.1Dhm/Ryr1+ miceRyr1tm1.1Dhm/Ryr1+involves: 129S2/SvPasCrl * 129S6/SvEvTac
Soleus myofiber abnormalities in Ryr1tm1.1Dhm/Ryr1+ miceRyr1tm1.1Dhm/Ryr1+involves: 129S2/SvPasCrl * 129S6/SvEvTac
Type 1 myofiber abnormalities in Ryr1tm1.1Dhm/Ryr1+ mouseRyr1tm1.1Dhm/Ryr1+involves: 129S2/SvPasCrl * 129S6/SvEvTac
Ryr1tm1.1Dhm/Ryr1+ newborns are weak and cyanotic and mice exhibit congenital myopathyRyr1tm1.1Dhm/Ryr1+involves: 129S2/SvPasCrl * 129S6/SvEvTac
Soleus muscle from Ryr1tm1.1Dhm/Ryr1+ mice shows variable fiber size and mild endomysial fibrosisRyr1tm1.1Dhm/Ryr1+involves: 129S2/SvPasCrl * 129S6/SvEvTac
Small size, abnormal posture, reduced skeletal muscle bulk, myotube abnormalities, and underdeveloped dermis in Ryr1tm1.1Dhm/Ryr1tm1.1Dhm neonatesRyr1tm1.1Dhm/Ryr1tm1.1Dhminvolves: 129S6/SvEvTac * 129X1/SvJ
Delayed ossification and cardiac development, subcutaneous edema, and an atrial septal closure defect in Ryr1tm1.1Dhm/Ryr1tm1.1Dhm fetusesRyr1tm1.1Dhm/Ryr1tm1.1Dhminvolves: 129S6/SvEvTac * 129X1/SvJ
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory