About   Help   FAQ
Phenotype Images associated with this Transgene
Nomenclature
Symbol: Tg(Vil1-cre/ERT2)23Syr
Name: transgene insertion 23, Sylvie Robine
MGI ID: MGI:3053826
Synonyms: TgvCreERT2, Tg(Vil-cre/ESR1)23Syr, vil-Cre-ERT2, vil-Cre-ERT2, villin-creERT2, villin::CreERT2, Villin-Cre(ER-T2), Villin-CreERT2
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Microvillus inclusion disease phenotype in Myo5btm1.1Cle/Myo5btm1.1Cle Tg(Vil1-cre/ERT2)23Syr/0 miceMyo5btm1.1Cle/Myo5btm1.1Cle
Tg(Vil1-cre/ERT2)23Syr/0		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2
Lower villus cells are the first cells affected in Myo5btm1.1Cle/Myo5btm1.1Cle/ Tg(Vil1-cre/ERT2)23Syr/0 mice, showing accumulation of vesicles and widened intercellular spacesMyo5btm1.1Cle/Myo5btm1.1Cle
Tg(Vil1-cre/ERT2)23Syr/0		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2
4-hydroxytamoxifen treated Vps35tm1.1Hckn/Vps35tm1.1Hckn Tg(Vil1-cre/ERT2)23Syr/0 mice exhibit no differences in small intestine crypt or villus morphologyVps35tm1.1Hckn/Vps35tm1.1Hckn
Tg(Vil1-cre/ERT2)23Syr/0		involves: 129P2/OlaHsd * C57BL/6 * DBA/2
(D) Vps35tm1.1Hckn/Vps35tm1.1Hckn/Tg(Vil1-cre/ERT2)23Syr/0 organoids show normal morphologyVps35tm1.1Hckn/Vps35tm1.1Hckn
Tg(Vil1-cre/ERT2)23Syr/0		involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Growth retardation of tamoxifen treated Slc39a4tm2Gka/Slc39a4tm2Gka Tg(Vil1-cre/ERT2)23Syr/0 miceSlc39a4tm2Gka/Slc39a4tm2Gka
Tg(Vil1-cre/ERT2)23Syr/0		involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Progressive disruption of intestinal villus integrity in tamoxifen treated Slc39a4tm2Gka/Slc39a4tm2Gka Tg(Vil1-cre/ERT2)23Syr/0 miceSlc39a4tm2Gka/Slc39a4tm2Gka
Tg(Vil1-cre/ERT2)23Syr/0		involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Progressive disruption of crypt architecture, loss of zinc, and reprogramming of Paneth cells in tamoxifen treated Slc39a4tm2Gka/Slc39a4tm2Gka Tg(Vil1-cre/ERT2)23Syr/0 miceSlc39a4tm2Gka/Slc39a4tm2Gka
Tg(Vil1-cre/ERT2)23Syr/0		involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory