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Phenotype Images associated with this Allele
Nomenclature
Symbol: Notch1tm2Rko
Name: notch 1; targeted mutation 2, Raphael Kopan
MGI ID: MGI:3044585
Synonyms: fN1, N1f, NICD1fl, Notch1f, Notch1flox, Notch1tm1Shn
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Corneal plaques and increased angiogenesis in the ear of Notch1tm2Rko/Notch1tm3(cre)Rko miceNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Notch1tm2Rko/Notch1tm3(cre)Rko mice develop vascular tumorsNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Tumor progression in Notch1tm2Rko/Notch1tm3(cre)Rko miceNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Embryonic lethality in Notch1tm2Rko/Notch1tm4(cre)Rko embryos due to the failure of angiogenic remodelingNotch1tm2Rko/Notch1tm4(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Notch1tm2Rko/Notch1tm3(cre)Rko mice show reactive splenomegaly to the inflammation in the liverNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Liver abnormalities and inflammation in Notch1tm2Rko/Notch1tm3(cre)Rko miceNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Well-differentiated hemangiosarcoma in Notch1tm2Rko/Notch1tm3(cre)Rko liverNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory