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Phenotype Images associated with this Transgene
Nomenclature
Symbol: Tg(Ins2-cre)23Herr
Name: transgene insertion 23, Pedro Luis Herrera
MGI ID: MGI:2387567
Synonyms: Ins(cre), InsCre, InsPr-Cre, (INSPr)-Cre, RIP-cre
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Loss of pancreatic beta-cells in aged Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr/0 miceHuwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
involves: C57BL/6J * CBA/J
Higher plasma insulin levels and increased pancreatic insulin content inCebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 miceCebpbtm1.1Maka/Cebpbtm1.1Maka
Tg(Ins2-cre)23Herr/0
involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Abnormal glucose and insulin homeostasis in Ins2Akita/Ins2Akita and Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 but not Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 mice.Cebpbtm1.1Maka/Cebpbtm1.1Maka
Ins2Akita/Ins2Akita
Tg(Ins2-cre)23Herr/0
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J
Ins2Akita/Ins2Akitainvolves: C57BL/6NSlc
Increased beta cell mass in Leprdb/Leprdb mice and Leprdb/Leprdb Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 miceLeprdb/LeprdbBKS.Cg-Dock7m +/+ Leprdb/Jcl
Cebpbtm1.1Maka/Cebpbtm1.1Maka
Leprdb/Leprdb
Tg(Ins2-cre)23Herr/0
involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J
Disorganized pancreatic islets in Glud1tm1.1Pma/Glud1tm1.1Pma Tg(Ins2-cre)23Herr/0 miceGlud1tm1.1Pma/Glud1tm1.1Pma
Tg(Ins2-cre)23Herr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J * SJL
Reduction in islet insulin content in Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+ Tg(Ins2-cre)23Herr/0 miceGt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+
Tg(Ins2-cre)23Herr/0
involves: 129S4/SvJae * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory