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Phenotype Images associated with this Transgene
Nomenclature
Symbol: Tg(Myh6-cre)2182Mds
Name: transgene insertion 2182, Michael D Schneider
MGI ID: MGI:2386742
Synonyms: alphaMhc-Cre, alpha-MHC-Cre+, alphaMyHC-Cre, MCH-cre, MHCalphaCre, MHCcre, MHC-Cre, Tg(Myhca-cre)2182Mds
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Enlarged, flaccid and flabby hearts in Med1tm2Jkr/Med1tm2Jkr Tg(Myh6-cre)2182Mds/0 mice by E25.Med1tm2Jkr/Med1tm2Jkr
Tg(Myh6-cre)2182Mds/0		involves: 129P2/OlaHsd * FVB/N
Heart sections of Med1tm2Jkr/Med1tm2Jkr Tg(Myh6-cre)2182Mds/0 heart reveal thinning of ventricular walls and dilation of chambers.Med1tm2Jkr/Med1tm2Jkr
Tg(Myh6-cre)2182Mds/0		involves: 129P2/OlaHsd * FVB/N
Cardiac fibrosis, increased cardiomyocyte apoptosis and mitochondrial damage in Med1tm2Jkr/Med1tm2Jkr Tg(Myh6-cre)2182Mds/0 mouse heartMed1tm2Jkr/Med1tm2Jkr
Tg(Myh6-cre)2182Mds/0		involves: 129P2/OlaHsd * FVB/N
Cardiac fibrosis in Med1tm2Jkr/Med1tm2Jkr A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ mouse heartMed1tm2Jkr/Med1tm2Jkr
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+		involves: 129P2/OlaHsd * FVB/N
Lethal cardiomyopathy in Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 miceYap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0		involves: 129S/SvEv * FVB/N
Cardiomyopathy in Wwtr1tm1.2Eno/Wwtr1tm1.2Eno Yap1tm1.1Eno/Yap1+ Tg(Myh6-cre)2182Mds/0 miceWwtr1tm1.1Eno/Wwtr1tm1.1Eno
Yap1tm1.1Eno/Yap1+
Tg(Myh6-cre)2182Mds/0		involves: 129S/SvEv * FVB/N
Cardiomyopathy in Wwtr1tm1.2Eno/Wwtr1+ Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 miceWwtr1tm1.1Eno/Wwtr1+
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0		involves: 129S/SvEv * FVB/N
Impaired neonatal heart regeneration in Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 miceYap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0		involves: 129S/SvEv * FVB/N
Wwtr1tm1.1Eno/Wwtr1tm1.1Eno Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice exhibit cardiac abnormalities and Wwtr1tm1.1Eno/Wwtr1+ Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 hearts show defects in proliferation and survivalWwtr1tm1.1Eno/Wwtr1+
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0		involves: 129S/SvEv * FVB/N
Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0		involves: 129S/SvEv * FVB/N
Sarcomere maturation is attenuated in Rhebtm1.1Otsu/Rhebtm1.1Otsu Tg(Myh6-cre)2182Mds/0 heartsRhebtm1.1Otsu/Rhebtm1.1Otsu
Tg(Myh6-cre)2182Mds/0		involves: 129 * C57BL/6J * FVB/N
Hearts of Gata4tm1.1Wtp/Gata4tm1Grg Tg(Myh6-cre)2182Mds/0 mice appear normalGata4tm1Grg/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0		involves: 129 * C57BL/6 * FVB/N
Increased cardiac fibrosis in Capns1tm1.1Otsu/Capns1tm1.1Otsu Tg(Myh6-cre)2182Mds/0 mice after transverse aortic constrictionCapns1tm1.1Otsu/Capns1tm1.1Otsu
Tg(Myh6-cre)2182Mds/0		involves: C57BL/6J * FVB/N
Plasma membrane damage in Capns1tm1.1Otsu/Capns1tm1.1Otsu Tg(Myh6-cre)2182Mds/0 heartsCapns1tm1.1Otsu/Capns1tm1.1Otsu
Tg(Myh6-cre)2182Mds/0		involves: C57BL/6J * FVB/N
Cardiomyocyte-specific deletion of Klf5 does not alter pressure overload-induced hypertrophy in Klf5tm2.1Rng/Klf5tm2.1Rng Tg(Myh6-cre)2182Mds/0 miceKlf5tm2.1Rng/Klf5tm2.1Rng
Tg(Myh6-cre)2182Mds/0		involves: C57BL/6 * FVB/N
Dilated cardiomyopathy in Zfpm2tm1Sho/Zfpm2tm2Sho Tg(Myh6-cre)2182Mds/0 miceZfpm2tm1Sho/Zfpm2tm2Sho
Tg(Myh6-cre)2182Mds/0		involves: 129S1/Sv * 129S7/SvEvBrd
Defective myocardial perfusion and coronary vasculature in adult Zfpm2tm1Sho/Zfpm2tm2Sho Tg(Myh6-cre)2182Mds/0 heartZfpm2tm1Sho/Zfpm2tm2Sho
Tg(Myh6-cre)2182Mds/0		involves: 129S1/Sv * 129S7/SvEvBrd
Reduced coronary microvasculature, decreased capillary density and increased fibrosis in Gata4tm1.1Wtp/Gata4tm1Sho Tg(Myh6-cre)2182Mds/0 heartsGata4tm1Sho/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0		involves: 129S6/SvEvTac * 129S7/SvEvBrd
Increased fibrosis in Zfpm2tm1Sho/Zfpm2tm2Sho Tg(Myh6-cre)2182Mds/0 heartsZfpm2tm1Sho/Zfpm2tm2Sho
Tg(Myh6-cre)2182Mds/0		involves: 129S1/Sv * 129S7/SvEvBrd
Edema, peripheral hemorrhage, and reduced coronary plexus in Gata4tm1.1Wtp/Gata4tm1Sho Nkx2-5tm1(cre)Rjs/Nkx2-5+ embryos and enlarged dilated ventricles and increased fibrosis in Gata4tm1.1Wtp/Gata4tm1Sho Tg(Myh6-cre)2182Mds/0 heartsGata4tm1Sho/Gata4tm1.1Wtp
Nkx2-5tm1(cre)Rjs/Nkx2-5+		involves: 129S6/SvEvTac * 129S7/SvEvBrd
Gata4tm1Sho/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0		involves: 129S6/SvEvTac * 129S7/SvEvBrd
Dilated cardiomyopathy in Dicer1tm1Smr/Dicer1tm1Smr Tg(Myh6-cre)2182Mds/0 heartsDicer1tm1Smr/Dicer1tm1Smr
Tg(Myh6-cre)2182Mds/0		involves: 129S7/SvEvBrd * FVB/N
Impaired cardiac function in Dicer1tm1Smr/Dicer1tm1Smr Tg(Myh6-cre)2182Mds/0 mutant heartsDicer1tm1Smr/Dicer1tm1Smr
Tg(Myh6-cre)2182Mds/0		involves: 129S7/SvEvBrd * FVB/N
Increase in interstitial and perivascular collagen in Lpltm1Ijg/Lpltm1Ijg Tg(Myh6-cre)2182Mds/0 heartsLpltm1Ijg/Lpltm1Ijg
Tg(Myh6-cre)2182Mds/0		involves: FVB/N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory