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Phenotype Images associated with this Transgene
Nomenclature
Symbol: H2az2Tg(Wnt1-cre)11Rth
Name: H2A.Z histone variant 2; transgene insertion 11, David H Rowitch
MGI ID: MGI:2386570
Synonyms: Tg(Wnt1-cre)11Rth, Wnt1cre, Wnt1Cre, Wnt1-Cre, Wnt1::Cre
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Evidence of inflammation in both the proximal and mid-colon of the Ednrbtm1Nrd/Ednrbtm1Nrd Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ H2az2Tg(Wnt1-cre)11Rth/0 animals
Peyer's Patches (PP) of Ednrbtm1Nrd/Ednrbtm1Nrd Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ H2az2Tg(Wnt1-cre)11Rth/0 animals are small in size but have normal architecture
The spleen of Ednrbtm1Nrd/Ednrbtm1Nrd Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ H2az2Tg(Wnt1-cre)11Rth/0 animals is small in size and has abnormal architecture
Reduced numbers of sympathetic and dorsal root ganglia neurons in Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi H2az2Tg(Wnt1-cre)11Rth/0 fetusesElp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * C57BL/6N * CBA/J
Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi H2az2Tg(Wnt1-cre)11Rth/0 fetuses exhibit a decreased inferior facial angle and increased mandibular retropositionElp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * C57BL/6N * CBA/J
Reduction in the number of TH+ neurons in the dorsal root ganglia of Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi H2az2Tg(Wnt1-cre)11Rth/0 embryosElp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * C57BL/6N * CBA/J
Reduction in the number of TrkA+ fibers in the dorsal horn of the spinal cord and in the skin of Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)WtsiH2az2Tg(Wnt1-cre)11Rth/0 fetusesElp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * C57BL/6N * CBA/J
Reduced sympathetic and parasympathetic innervation of the submandibular gland in Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi H2az2Tg(Wnt1-cre)11Rth/0 embryosElp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * C57BL/6N * CBA/J
Mandibular hypoplasia and cleft palate in Map3k7tm1Mis/Map3k7tm1MisH2az2Tg(Wnt1-cre)11Rth/0 miceMap3k7tm1Mis/Map3k7tm1Mis
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * CBA/J
Palatal shelves of Map3k7tm1Mis/Map3k7tm1Mis H2az2Tg(Wnt1-cre)11Rth/0 mice show delayed rugal formationMap3k7tm1Mis/Map3k7tm1Mis
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * CBA/J
Ror1tm1.1Meg/Ror1tm1.1Meg Ror2tm1.1Meg/Ror2tm1.1Meg H2az2Tg(Wnt1-cre)11Rth/0 embryos exhibit sympathetic axon branching defectsRor1tm1.1Meg/Ror1tm1.1Meg
Ror2tm1.1Meg/Ror2tm1.1Meg
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: 129S4/SvJae * C57BL/6J * CBA/J
Effects of Cre-mediated rescue of Chd7Gt(XK403)Byg mutation on the arch artery phenotype at E10.5Chd7Gt(XK403)Byg/Chd7+involves: 129P2/OlaHsd * C57BL/6
Chd7Gt(XK403)Byg/Chd7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+		either: (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA/J) or (involves: 129P2/OlaHsd * C57BL/6J * CBA/J * CD-1)
Chd7Gt(XK403)Byg/Chd7+
Tg(Tbx1-cre)1Joe/0		either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)
Chd7Gt(XK403)Byg/Chd7+
Tfap2atm1(cre)Moon/Tfap2a+		either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)
Craniofacial malformation in Ext1tm1Yama/Ext1tm1YamaH2az2Tg(Wnt1-cre)11Rth/0 miceExt1tm1Yama/Ext1tm1Yama
H2az2Tg(Wnt1-cre)11Rth/H2az2+		B6.Cg-H2az2Tg(Wnt1-cre)11Rth Ext1tm1Yama
Peters-like anomaly in Ext1tm1Yama/Ext1tm1Yama H2az2Tg(Wnt1-cre)11Rth/0 miceExt1tm1Yama/Ext1tm1Yama
H2az2Tg(Wnt1-cre)11Rth/H2az2+		B6.Cg-H2az2Tg(Wnt1-cre)11Rth Ext1tm1Yama
Neural crest cell proliferation in the anterior chamber of Ext1tm1Yama/Ext1tm1Yama H2az2Tg(Wnt1-cre)11Rth/0 mice is disturbedExt1tm1Yama/Ext1tm1Yama
H2az2Tg(Wnt1-cre)11Rth/H2az2+		B6.Cg-H2az2Tg(Wnt1-cre)11Rth Ext1tm1Yama
Thin cornea and iridocorneal dysgenesis in Ext1tm1Yama/Ext1+ H2az2Tg(Wnt1-cre)11Rth/0 Tgfb2tm1Doe/Tgfb2+ miceExt1tm1Yama/Ext1+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tgfb2tm1Doe/Tgfb2+		B6.Cg-Tgfb2tm1Doe H2az2Tg(Wnt1-cre)11Rth Ext1tm1Yama
Aberrant iridocorneal development in Ext1tm1Yama/Ext1+ H2az2Tg(Wnt1-cre)11Rth/0 Tgfb2tm1Doe/Tgfb2+ miceExt1tm1Yama/Ext1+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tgfb2tm1Doe/Tgfb2+		B6.Cg-Tgfb2tm1Doe H2az2Tg(Wnt1-cre)11Rth Ext1tm1Yama
Skeletal image of newborn Sox9tm2Crm/Sox9tm2Crm H2az2Tg(Wnt1-cre)11Rth/0 miceSox9tm2Crm/Sox9tm2Crm
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: 129S7/SvEvBrd * C57BL/6 * CBA
Skeletal preparations of wild-type and Sox9tm2Crm/Sox9tm2Crm H2az2Tg(Wnt1-cre)11Rth/0 embryosSox9tm2Crm/Sox9tm2Crm
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: 129S7/SvEvBrd * C57BL/6 * CBA
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory