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Phenotype Images associated with this Allele
Nomenclature
Symbol: Destm1Cap
Name: desmin; targeted mutation 1, Yassemi Capetanaki
MGI ID: MGI:2178321
Synonyms: desm1
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Cardiac fibrosis and calcification seen in Destm1Cap/Destm1Cap mice is reduced in Destm1Cap/Destm1Cap Tg(Bcl2)ACap/Tg(Bcl2)ACap and Destm1Cap/Destm1Cap Tg(Bcl2)BCap/Tg(Bcl2)BCap miceDestm1Cap/Destm1Cap
Tg(Bcl2)ACap/Tg(Bcl2)ACap
involves: 129S7/SvEvBrd * C57BL/6
Destm1Cap/Destm1Cap
Tg(Bcl2)BCap/Tg(Bcl2)BCap
involves: 129S7/SvEvBrd * C57BL/6
Destm1Cap/Destm1Capinvolves: 129S7/SvEvBrd
Ultrastructural cardiomyocyte abnormalities seen in Destm1Cap/Destm1Cap mice are reduced in Destm1Cap/Destm1Cap Tg(Bcl2)ACap/Tg(Bcl2)ACap miceDestm1Cap/Destm1Cap
Tg(Bcl2)BCap/Tg(Bcl2)BCap
involves: 129S7/SvEvBrd * C57BL/6
Destm1Cap/Destm1Capinvolves: 129S7/SvEvBrd
Myocardium degeneration and calcification in Destm1Cap/Destm1Cap miceDestm1Cap/Destm1Capinvolves: 129S7/SvEvBrd * C57BL/6
Progressive degeneration of cardiac muscle in Destm1Cap/Destm1Cap miceDestm1Cap/Destm1Capinvolves: 129S7/SvEvBrd * C57BL/6
Destm1Cap/Destm1Cap mice exhibit disorganized cardiac myofibrilsDestm1Cap/Destm1Capinvolves: 129S7/SvEvBrd * C57BL/6
Skeletal muscle abnormalities in Destm1Cap/Destm1Cap miceDestm1Cap/Destm1Capinvolves: 129S7/SvEvBrd * C57BL/6
Severely disrupted skeletal myofibrils in Destm1Cap/Destm1Cap diaphragmDestm1Cap/Destm1Capinvolves: 129S7/SvEvBrd * C57BL/6
Smooth muscle abnormalities in Destm1Cap/Destm1Cap miceDestm1Cap/Destm1Capinvolves: 129S7/SvEvBrd * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory