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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ldlrtm1Her
Name: low density lipoprotein receptor; targeted mutation 1, Joachim Herz
MGI ID: MGI:1857212
Synonyms: LDLR-, LDLr0, LDLrKO, LDLr-KO, LDLR KO, Ldlrtm1Her
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Atherosclerosis lesion area is increased in Ldlrtm1Her/Ldlrtm1Her Nr1h3tm1.1Djm/Nr1h3tm1.1Djm Speer6-ps1Tg(Alb-cre)21Mgn/0 mice and TO901317 treatment reduces these lesionsLdlrtm1Her/Ldlrtm1Her
Nr1h3tm1.1Djm/Nr1h3tm1.1Djm
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+		involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
Increase in macrophage content in Ldlrtm1Her/Ldlrtm1Her Nr1h3tm1.1Djm/Nr1h3tm1.1Djm Speer6-ps1Tg(Alb-cre)21Mgn/0 aortic rootLdlrtm1Her/Ldlrtm1Her
Nr1h3tm1.1Djm/Nr1h3tm1.1Djm
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+		involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
Adiposity in Ldlrtm1Her/Ldlrtm1Her and Scd1ab-2J/Scd1ab-2J Ldlrtm1Her/Ldlrtm1Her miceLdlrtm1Her/Ldlrtm1HerB6.129S7-Ldlrtm1Her
Ldlrtm1Her/Ldlrtm1Her
Scd1ab-2J/Scd1ab-2J		B6.Cg-Ldlrtm1Her Scd1ab-2J
Hepatic lipids in Ldlrtm1Her/Ldlrtm1Her and Scd1ab-2J/Scd1ab-2J Ldlrtm1Her/Ldlrtm1Her miceLdlrtm1Her/Ldlrtm1HerB6.129S7-Ldlrtm1Her
Ldlrtm1Her/Ldlrtm1Her
Scd1ab-2J/Scd1ab-2J		B6.Cg-Ldlrtm1Her Scd1ab-2J
Phenotype of aortic arch atherosclerotic lesions in Tbx21tm1Glm/Tbx21tm1Glm Ldlrtm1Her/Ldlrtm1Her and Ldlrtm1Her/Ldlrtm1Her miceLdlrtm1Her/Ldlrtm1Herinvolves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Ldlrtm1Her/Ldlrtm1Her
Tbx21tm1Glm/Tbx21tm1Glm		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Cutaneous xanthomatosis and alopecia in Soat1tm1Ishi/Soat1tm1Ishi Apoetm1Unc/Apoetm1Unc and Soat1tm1Ishi/Soat1tm1Ishi Ldlrtm1Her/Ldlrtm1Her miceSoat1tm1Ishi/Soat1tm1Ishi
Apoetm1Unc/Apoetm1Unc		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Soat1tm1Ishi/Soat1tm1Ishi
Ldlrtm1Her/Ldlrtm1Her		involves: 129S7/SvEvBrd * C57BL/6
Histopathology of cutaneous lesions developed in Soat1tm1Ishi/Soat1tm1Ishi Apoetm1Unc/Apoetm1Unc and Soat1tm1Ishi/Soat1tm1Ishi Ldlrtm1Her/Ldlrtm1Her mice fed high fat dietsSoat1tm1Ishi/Soat1tm1Ishi
Apoetm1Unc/Apoetm1Unc		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Soat1tm1Ishi/Soat1tm1Ishi
Ldlrtm1Her/Ldlrtm1Her		involves: 129S7/SvEvBrd * C57BL/6
Soat1tm1Far/Soat1tm1Far Ldlrtm1Her/Ldlrtm1Her mice fed an atherogenic diet for 2 months display severe xanthomatosisLdlrtm1Her/Ldlrtm1Her
Soat1tm1Far/Soat1tm1Far		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Neutral lipid-poor atherosclerotic lesions in Apoetm1Unc/Apoetm1Unc Soat1tm1Far/Soat1tm1Far and Soat1tm1Far/Soat1tm1Far Ldlrtm1Her/Ldlrtm1Her miceApoetm1Unc/Apoetm1Unc
Soat1tm1Far/Soat1tm1Far		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
Ldlrtm1Her/Ldlrtm1Her
Soat1tm1Far/Soat1tm1Far		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory