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Phenotype Image Detail
Image
Caption Histological analysis of cerebellum and spinal cord from a sick Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0 mouse with ataxia and classical paralysis. Cerebellum (I-IV) and spinal cord (V-VIII) showed severe infiltration, demyelination, and axonal damage as visualized by immunohistochemistry using anti-CD3 (I and V) and anti-Mac3 antibodies (II and VI), Luxol fast blue staining (III and VII), and Bielschowsky silver impregnation (IV and VIII). I, II, V, and VI were counterstained by hematoxylin and eosin (H&E). Magnification: X17 (cerebellum) and X30 (spinal cord). Bars, 1 mm. Data are representative of at least two independent experiments consisting of more than three mice per group.
Copyright This image is from Pollinger B, J Exp Med 2009 Jun 8;206(6):1303-16, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:149511
Associated
Alleles
Symbol Name
Tg(H2-Kb-Tcra,-Tcrb)1640Kurs transgene insertion 1640, Florian C Kurschus
Associated
Genotypes
Allelic Composition Genetic Background
Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0 SJL.FVB-Tg(H2-Kb-Tcra,-Tcrb)1640Kurs

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory