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Phenotype Image Detail
Image
Caption IL-21R deficiency prevents renal disease and mortality characteristic of BXSB-Yaa mice. (A and B) Kidney sections from 16-week-old Il21rtm1Wjl/Il21r+ X/Yaa (Il21r+/-) and Il21rtm1Wjl/Il21rtm1Wjl X/Yaa (Il21-/-) mice were stained with H&E, periodic acid/Schiff reagent (PAS), or Masson's trichrome. (A) Representative sections. Kidneys of Il21rtm1Wjl/Il21r+ X/Yaa (Il21r+/-) mice exhibited multiple pathological features, including a thickening of the glomerular basement membrane, perivascular inflammation associated with neutrophilic infiltrates, and focal adhesions with marked glomerular fibrosis, sclerosis, and Ig deposits. In contrast, kidneys from Il21rtm1Wjl/Il21rtm1Wjl X/Yaa (Il21-/-) mice were essentially free of all these abnormalities.
Copyright This image is from Bubier JA, Proc Natl Acad Sci U S A 2009 Feb 3;106(5):1518-23. Copyright 2009 National Academy of Sciences, U.S.A. J:144484
Associated
Alleles
Symbol Name
Il21rtm1Wjl interleukin 21 receptor; targeted mutation 1, Warren J Leonard
Yaa accelerated autoimmunity and lymphoproliferation transposition; accelerated autoimmunity and lymphoproliferation
Associated
Genotypes
Allelic Composition Genetic Background
Il21rtm1Wjl/Il21rtm1Wjl
X/Yaa
BXSB.129(Cg)-Il21rtm1Wjl/Dcr

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory