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Phenotype Image Detail
Image
Caption After fixation of 18 month-old mice animals, 50 mm coronal sections were stained with Thioflavin T to label beta-amyloid plaques. A) Tg(APPswe,PSEN1dE9)85Dbo/0 (Swede) mouse. White arrows indicate plaques in the orbital frontal cortex and anterior olfactory cortex, respectively. B) 18 month-old control mouse without any plaque staining. C) A Z-stack showing a 10 mm diameter plaque, one of the larger ones observed. D) A middle tufted cell of the olfactory bulb showing Tau tangle phenotype in a tested Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/0 (Tau) mouse.
Copyright This image is from Phillips M, PLoS One 2011;6(5):e19567, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172426
Associated
Alleles
Symbol Name
Mapttm1(EGFP)Klt microtubule-associated protein tau; targeted mutation 1, Kerry Lee Tucker
Tg(APPswe,PSEN1dE9)85Dbo transgene insertion 85, David R Borchelt
Tg(MAPT)8cPdav transgene insertion 8c, Peter Davies
Associated
Genotypes
Allelic Composition Genetic Background
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/0
B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
Tg(APPswe,PSEN1dE9)85Dbo/0 B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory